Protein Alignment klhl10 and Klhl4

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_766369.2
• Gene: Klhl4 / 237010
• MGIID: 2442829
• Length: 717
• Species: Mus musculus
• Alignment Length: 651
• Identity: 187/651 - (28%)
• Similarity: 314/651 - (48%)
• Gaps: 64/651 - (9%)

  Fly     3 RNQNESNL---LDINEDLPFAL--------ALPPVSMDSLQLNADGN-----------SPEDKTL 45
            :|.::.|:   |..|||.|.|:        |....|.| |::..|.|           .||..|
Mouse    89 QNWHQQNVIVHLQANEDTPKAVPEGNLLKEACEKRSRD-LEMMGDDNIEDMRAGPCVEEPEQMT- 151

  Fly    46 GIGRKTILNAHTKSLAPIVSDEALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQ 110
                 |..|.|.:|.:.  :|..|..:....::..|||..:..|......||.::.:.|.||.|.
Mouse   152 -----TSSNDHYRSRSH--ADYTLCKMESYLKERKLCDVLLIAGPLKIPAHRLVLSAVSDYFAAM 209

  Fly   111 FTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGM 175
            ||.         |..:|::..  :.|.||....:|.::||||.....:.|..:..||..|..:.:
Mouse   210 FTN---------DVLEARQEE--VKIEGVDPNALNSLVQYAYTGVLQLREDTIENLLSAACLLQL 263

  Fly   176 VGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDF 240
            ..::..|.::|.:.|.|.||:.|..|...:...:|...|..|.:.:|.:| .:|.:.|.:.|.:.
Mouse   264 TQVIDVCCNFLIKQLHPSNCLGIRSFGDAQGCMELQNVAHKYAMEHFIDV-IKNQEFLLLPANEI 327

  Fly   241 YSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYV-- 303
            ..::..|::|..:|:.::...::|:..:.::|:|.:|.|::.:||.|::|: .:.:::...:.
Mouse   328 SKLLCSDDINVPDEETIFHALMQWVGHDAQARQRDLAKLLSYIRLPLLSPQ-LLADLENSSFFSG 391

  Fly   304 -LECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLAMPRLPH-EVIFAIGGWSGGTSKGCIETY 366
             |||:   .|:::..|:     .|.|:...:...|...||... ..::|:||.........||.|
Mouse   392 NLECQ---KLLMEAMKY-----HLLPERRSMLQSPRTKPRKSTVGALYAVGGMDAAKGTTTIEKY 448

  Fly   367 DTRADRWVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDAVKKKWNEIAPMHCR 431
            |.|.:.|:.|..  .:|.|...|.||:..|::.:||.||::..||...|:.|.|.|..:.||...
Mouse   449 DLRTNSWIHIGT--MSGRRLQFGVAVVDNKLYVVGGRDGLKTLNTVECFNPVTKTWVVMPPMSTH 511

  Fly   432 RCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGG 496
            |..:.|..|.|.:||:||:||.:.||||||::|...||:.:..|:..||......|..|:||.||
Mouse   512 RHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPDGRQWNYVASMSTPRSTVGVVALNNRLYAIGG 576

  Fly   497 FNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGF-----NGTARLS-TGER 555
            .:|..||.|.|::||.||.|:....|:.||.||........|||:||.     |..:||| ..||
Mouse   577 RDGSSCLKSMEFFDPHTNKWSLCAPMSKRRGGVGVATHNGYLYVVGGHDAPAPNHCSRLSDCVER 641

  Fly   556 FDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEATDMNIVR 620
            :||...:|..:..::..|....:..:.|.::.:||::|.:.::..|.|.|:.|||.|...:||.|
Mouse   642 YDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQKDEWKEEVPVNIGR 706

  Fly   621 S 621
            :
Mouse   707 A 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	10/45 (22%)
		PHA03098	86..610	CDD:222983	155/533 (29%)
		KELCH repeat	385..428	CDD:276965	15/42 (36%)
		KELCH repeat	432..475	CDD:276965	19/42 (45%)
		KELCH repeat	479..523	CDD:276965	18/43 (42%)
		KELCH repeat	526..571	CDD:276965	17/50 (34%)
		KELCH repeat	573..617	CDD:276965	12/43 (28%)
Klhl4	NP_766369.2	PHA03098	175..697	CDD:222983	159/544 (29%)
		KELCH repeat	465..508	CDD:276965	15/42 (36%)
		KELCH repeat	512..556	CDD:276965	19/43 (44%)
		KELCH repeat	559..602	CDD:276965	18/42 (43%)
		KELCH repeat	606..657	CDD:276965	17/50 (34%)
		KELCH repeat	659..698	CDD:276965	11/38 (29%)