Protein Alignment klhl10 and Klhl15

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_001034150.1
• Gene: Klhl15 / 236904
• MGIID: 1923400
• Length: 604
• Species: Mus musculus
• Alignment Length: 588
• Identity: 144/588 - (24%)
• Similarity: 244/588 - (41%)
• Gaps: 89/588 - (15%)

  Fly    75 LREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGV 139
            |.|:.||.|..:.:.:..|..|:|::.:.|.|||..||   ||.        .:::.:.||:.|:
Mouse    24 LYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFT---ADM--------RERDQDKIHLKGL 77

  Fly   140 SSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARF 204
            ::...:.|:|:.|.....:|.:.|||:|..|.||.::.:||.|..:|...:..|||..||
Mouse    78 TATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIM----- 137

  Fly   205 RFLEDLHL-------KARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCV 262
            |.|:|..:       |...:.|..|..:..|...:..:|.|...|.:.:|.|:...|..:::...
Mouse   138 RLLDDFGVNIEGVREKLDAFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQ 202

  Fly   263 KWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYV-----LECEAAKPLIVDTFKFMYD 322
            .|: |:...|.||...::..:|..||||....|:||...:.     |..|..:.|  :.|:.::.
Mouse   203 SWL-RHDRRRWRHTDTIIQNIRFCLMTPSSVFEKVKTSEFYRYSRQLRYEVDQAL--NYFQNVHQ 264

  Fly   323 LDFLNPQADELTTPPLAMPRLPHEVIF-AIGGWSGGTSKGCIETYDTRADR--WVTINAEDPAGP 384
            ...|:.::..:.:..      |...:| .:.|.|...||..:    .:..|  |   ..|.|..|
Mouse   265 QPLLDMKSSRIRSAK------PQTTVFRGMIGHSMVNSKILL----LKKPRVWW---ELEGPQVP 316

  Fly   385 RAYHGTAVLGFKIFSIGGY----DGVEYFNTCRVF--DAVKKKWNEIAPMHCRRCYVSVTELNGM 443
            ......|::...:|.:||.    || |:..:.:||  |..:..|..:|.|...|...:|..:...
Mouse   317 LRPDCLAIVNNFVFLLGGEELGPDG-EFHASSKVFRYDPRQNSWLRMADMSVPRSEFAVGVIGKF 380

  Fly   444 IYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNGQECLDSAEY 508
            |||:.|........:.|||:...::|..:.|..:.:.......|..:::.|||............
Mouse   381 IYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCV 445

  Fly   509 YDP---------------VTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLS------- 551
            :||               |||.|.....||:.|.....:::..:|||.||.....|.|
Mouse   446 FDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCP 510

  Fly   552 TGERFDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGG--FNG-----VSTISHTECYVAETDE 609
            :.|.::|||..|..:..|...||..|:.::|..|..:||  :||     :.|....|      ::
Mouse   511 STEVYNPDTDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHYSDSILTFDPDE------NK 569

  Fly   610 WME 612
            |.|
Mouse   570 WKE 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	10/32 (31%)
		PHA03098	86..610	CDD:222983	137/573 (24%)
		KELCH repeat	385..428	CDD:276965	12/48 (25%)
		KELCH repeat	432..475	CDD:276965	10/42 (24%)
		KELCH repeat	479..523	CDD:276965	10/58 (17%)
		KELCH repeat	526..571	CDD:276965	14/51 (27%)
		KELCH repeat	573..617	CDD:276965	13/47 (28%)
Klhl15	NP_001034150.1	BTB_POZ_KLHL15	1..137	CDD:349553	37/123 (30%)
		PHA03098	33..576	CDD:222983	139/579 (24%)
		BACK_KLHL15	128..235	CDD:350529	28/112 (25%)
		KELCH repeat	321..365	CDD:276965	12/44 (27%)
		Kelch 1	328..379		14/51 (27%)
		KELCH repeat	369..412	CDD:276965	10/42 (24%)
		Kelch 2	381..426		10/44 (23%)
		KELCH repeat	417..474	CDD:276965	10/56 (18%)
		Kelch 3	428..473		9/44 (20%)
		KELCH repeat	478..529	CDD:276965	13/50 (26%)
		Kelch 4	489..542		16/52 (31%)
		KELCH repeat	532..572	CDD:276965	12/45 (27%)
		Kelch 5	544..590		9/35 (26%)