Protein Alignment klhl10 and KLHL18

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: XP_005265058.2
• Gene: KLHL18 / 23276
• HGNCID: 29120
• Length: 584
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 160/566 - (28%)
• Similarity: 255/566 - (45%)
• Gaps: 78/566 - (13%)

  Fly    72 LNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHI 136
            :.|:|.|..|||..:.:|:..|:.||.::.:...||.|.||.         |..:.|::.  |.:
Human    28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTN---------DMMECKQDE--IVM 81

  Fly   137 PGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGF 201
            .|:....:..:|.:||.....|.:.||..||:.|.::.:..:...|..:|...|.|:||:.:..|
Human    82 QGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146

  Fly   202 ARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWID 266
            |.......|:..|.::..::|.||:... :.|.:..||...::|.||||.:.|:.|::..:.|:.
Human   147 AETMMCAVLYDAANSFIHQHFVEVSMSE-EFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVR 210

  Fly   267 RNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFLNPQAD 331
            .:.|.|..::..|::.:||.|..|:...:.|::...|..|...:.|:                 |
Human   211 YDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLV-----------------D 258

  Fly   332 ELTTPPLAMPRLPHEVIFAIGGWSGGTSKGCIETYDTRADRWVTINAEDPAGPRAYHGTAVLGFK 396
            |.....|...|.||                 :..:.||              ||..  |::.|.
Human   259 EAKDYHLMPERRPH-----------------LPAFRTR--------------PRCC--TSIAGL- 289

  Fly   397 IFSIGGYDGVEYF------NTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNR 455
            |:::||.:....|      |...|||.:...|....||...|..|.|..:||::||||||||..|
Human   290 IYAVGGLNSAANFYAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLR 354

  Fly   456 LNTVERYNPRTNQWSVIPPMNMQRSDASAC-------TLQERIYATGGFNGQECLDSAEYYDPVT 513
            |:|||.|||.|:.|:.:..||.:||  |.|       .|..:||..||::|...|.|.|.|.|.|
Human   355 LSTVEAYNPETDTWTRVGSMNSKRS--SVCFSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPET 417

  Fly   514 NVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDPDTQTWHFIREMNHSRSNFGL 578
            :.||.:.:|:..||......|..::||.||.:|....|:.|.::..|.|||....|.:.|...|.
Human   418 DKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGA 482

  Fly   579 EIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEATDMNIVRSALS 624
            ..:...:|..||::|...:|..|.|.:..|:|.....|:..||.:|
Human   483 ASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVS 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	11/35 (31%)
		PHA03098	86..610	CDD:222983	149/536 (28%)
		KELCH repeat	385..428	CDD:276965	12/48 (25%)
		KELCH repeat	432..475	CDD:276965	23/42 (55%)
		KELCH repeat	479..523	CDD:276965	18/50 (36%)
		KELCH repeat	526..571	CDD:276965	15/44 (34%)
		KELCH repeat	573..617	CDD:276965	11/43 (26%)
KLHL18	XP_005265058.2	BTB_POZ_KLHL18	19..134	CDD:349556	30/116 (26%)
		PHA03098	34..562	CDD:222983	158/560 (28%)
		BACK_KLHL18	135..241	CDD:350532	29/106 (27%)
		KELCH repeat	282..327	CDD:276965	11/47 (23%)
		KELCH repeat	331..374	CDD:276965	23/42 (55%)
		KELCH repeat	378..427	CDD:276965	18/50 (36%)
		KELCH repeat	430..474	CDD:276965	14/43 (33%)
		KELCH repeat	477..521	CDD:276965	11/43 (26%)
		KELCH repeat	524..567	CDD:276965	3/5 (60%)