Protein Alignment klhl10 and Klhl20

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_001034571.1
• Gene: Klhl20 / 226541
• MGIID: 2444855
• Length: 604
• Species: Mus musculus
• Alignment Length: 614
• Identity: 193/614 - (31%)
• Similarity: 274/614 - (44%)
• Gaps: 84/614 - (13%)

  Fly    44 TLGIGRKTILNAHTKSLAPIVSD----EALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCS 104
            |||...|........:..|.:||    :.|..:|.||:...|||..:.||......||.|:.:||
Mouse    21 TLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACS 85

  Fly   105 SYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLIC 169
            .||||.||           |..|:.....:.|..:....|..:|.:||..|..:.|.||..||..
Mouse    86 PYFRAMFT-----------GELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPA 139

  Fly   170 ADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILD 234
            |..:.:..:.:.|.::|.|.|.|.||:.|..||......:|...|..:|...|.|| ..:.:.:.
Mouse   140 ACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEV-MESEEFML 203

  Fly   235 MSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKE 299
            :.|.....|||.||||.|.|:.|:...:.|:..:.:.|:..:..::..|||.|::||..:..|..
Mouse   204 LPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGS 268

  Fly   300 HPYVLECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLAMPRLP---HEVIFAIGGWSGGTSKG 361
            .|.:...|..:.|:.:...::     |.||...|...|...||.|   .||:||:|||..|.:..
Mouse   269 DPLIKSDEECRDLVDEAKNYL-----LLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAIS 328

  Fly   362 CIETYDTRADRW----------------------------------VTINAEDP--------AGP 384
            .:|.||.:.:.|                                  .::...||        ..|
Mouse   329 SVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAP 393

  Fly   385 ----RAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIY 445
                |...|.||||..::::||.|||...|....:|..:.||..:|.|..||..|:|..|.|.:|
Mouse   394 TSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLY 458

  Fly   446 AIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNGQECLDSAEYYD 510
            |:||.||.:.|||||||||:.|:|..|.||..:|........|:.|||.||.:....|.|||.|:
Mouse   459 AVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYN 523

  Fly   511 PVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDPDTQTWHFIREMNHSRSN 575
            |.||.|:.:..|..|||||.......||..:|||:||..|.|.|.||||..||.....||:.|
Mouse   524 PRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRR-- 586

  Fly   576 FGLEIIDDMIFAIGGFNGVSTISHTECYV 604
                        :||..||..::|.|.::
Mouse   587 ------------LGGGVGVIKMTHCESHI 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	18/49 (37%)
		PHA03098	86..610	CDD:222983	179/568 (32%)
		KELCH repeat	385..428	CDD:276965	16/42 (38%)
		KELCH repeat	432..475	CDD:276965	23/42 (55%)
		KELCH repeat	479..523	CDD:276965	16/43 (37%)
		KELCH repeat	526..571	CDD:276965	21/44 (48%)
		KELCH repeat	573..617	CDD:276965	7/32 (22%)
Klhl20	NP_001034571.1	BTB_POZ_KLHL20_KLEIP	40..167	CDD:349558	43/137 (31%)
		PHA03098	58..581	CDD:222983	173/539 (32%)
		Kelch 1	314..360		11/45 (24%)
		KELCH repeat	350..394	CDD:276965	2/43 (5%)
		Kelch 2	362..408		8/45 (18%)
		KELCH repeat	398..442	CDD:276965	16/43 (37%)
		Kelch 3	409..455		16/45 (36%)
		KELCH repeat	445..490	CDD:276965	25/44 (57%)
		Kelch 4	457..502		21/44 (48%)
		KELCH repeat	492..535	CDD:276965	16/42 (38%)
		Kelch 5	504..549		20/44 (45%)
		KELCH repeat	539..584	CDD:276965	21/44 (48%)
		Kelch 6	551..596		22/58 (38%)