Protein Alignment klhl10 and Gan

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_001074620.1
• Gene: Gan / 209239
• MGIID: 1890619
• Length: 597
• Species: Mus musculus
• Alignment Length: 601
• Identity: 155/601 - (25%)
• Similarity: 262/601 - (43%)
• Gaps: 66/601 - (10%)

  Fly    64 VSD-----EALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVD 123
            |||     ..|..|:..||:...|||.:.:..:...|.:.|:.:.|.|.|.:. .:|   |...|
Mouse     7 VSDPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKL-NYN---PPKDD 67

  Fly   124 GSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGR 188
            ||..|     |.:.|:|..:|..::.|.:..|..::|..:.:::..||.:.:..|...|.::|..
Mouse    68 GSTYK-----IELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEG 127

  Fly   189 ILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTRE 253
            .:..|||:.|..||....|..:|..|..|...:|.:|:... :.|::|.:....:||.::||...
Mouse   128 CIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTE-EFLELSPQKLKEVISLEKLNVGN 191

  Fly   254 EDHVWKLCVKWIDRNPESRKRHVAHLMTGVRL-GLMTPKCFMEEVKEHPYVLECEAAKPLIVDTF 317
            |.:|::..::||..:.|.||.|:..:|:.:.: ||           :..|:.|....:||:.:..
Mouse   192 ERYVFEAVIRWIAHDVEMRKVHMKDVMSALWVSGL-----------DSSYLREQMLNEPLVREIV 245

  Fly   318 KFMYDLDFLNPQADELTTPPLAM-----PRLPHEVIFAIGGWSGGTSK-----GCI-ETYDTRAD 371
            |...::....||..|      ||     ||...|.|..|||....:.|     .|: ..||....
Mouse   246 KECSNIPLSQPQQGE------AMLASFKPRGYSECIVTIGGEERVSRKPTAAMRCMCPLYDPNRQ 304

  Fly   372 RWVTINAEDPAG-PRAYHGT-AVLGFKIFSIGGYD-GVEYFNTCRVFDAVKKKWNEIAPMHCRRC 433
            .|:.:   .|.. ||..||. :..|| :|.:||.| ..:..::...:|.....|..:.|||..|.
Mouse   305 LWIEL---APLSMPRINHGVLSAEGF-LFVLGGQDENKQTLSSGEKYDPDANTWTALPPMHEARH 365

  Fly   434 YVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFN 498
            ...:.|::||:|.:||.||...|.::|.|:..:..|:..|.:.|.|.......::::|||.||.:
Mouse   366 NFGIVEIDGMLYILGGEDGDRELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGS 430

  Fly   499 GQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGG------FNGTARLSTGERFD 557
            ..:..:|.|.|||.|..||.|..:..||.|........:|||.||      ..|:..::....|.
Mouse   431 YGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDIQGSEMVTCKSEFY 495

  Fly   558 PDT-QTWHFIREMN-----HSRSNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEATDM 616
            .|. :.|.::.:.|     .|...:|...|...|:.||..:..:...:...:...|..|.....:
Mouse   496 HDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTGTWHHTKPL 560

  Fly   617 ---NIVRSALSANNIA 629
               ::.|:..:|..||
Mouse   561 LPSDLRRTGCAALRIA 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	14/48 (29%)
		PHA03098	86..610	CDD:222983	140/550 (25%)
		KELCH repeat	385..428	CDD:276965	11/44 (25%)
		KELCH repeat	432..475	CDD:276965	14/42 (33%)
		KELCH repeat	479..523	CDD:276965	15/43 (35%)
		KELCH repeat	526..571	CDD:276965	12/56 (21%)
		KELCH repeat	573..617	CDD:276965	7/46 (15%)
Gan	NP_001074620.1	BTB_POZ_KLHL16_gigaxonin	16..126	CDD:349554	29/118 (25%)
		PHA03098	28..502	CDD:222983	134/504 (27%)
		BACK_KLHL16_gigaxonin	130..226	CDD:350530	27/96 (28%)
		Kelch 1. /evidence=ECO:0000255	274..326		14/54 (26%)
		KELCH repeat	316..360	CDD:276965	11/44 (25%)
		Kelch 2. /evidence=ECO:0000255	327..374		12/47 (26%)
		KELCH repeat	364..408	CDD:276965	14/43 (33%)
		Kelch 3. /evidence=ECO:0000255	376..421		12/44 (27%)
		KELCH repeat	411..456	CDD:276965	15/44 (34%)
		Kelch 4. /evidence=ECO:0000255	422..468		17/45 (38%)
		KELCH repeat	458..511	CDD:276965	12/52 (23%)
		Kelch 5. /evidence=ECO:0000255	470..522		11/51 (22%)
		KELCH repeat	514..561	CDD:276965	8/46 (17%)
		Kelch 6. /evidence=ECO:0000255	528..574		7/45 (16%)