Protein Alignment klhl10 and Klhl29

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_001157965.1
• Gene: Klhl29 / 208439
• MGIID: 2683857
• Length: 875
• Species: Mus musculus
• Alignment Length: 615
• Identity: 157/615 - (25%)
• Similarity: 267/615 - (43%)
• Gaps: 57/615 - (9%)

  Fly    24 PPVSMDSLQLNAD---GNSPED----------KTLGIGRKTILN-AHTKSLAPIVSDEALNTLNE 74
            ||.:..|..|.:.   .|.|..          :|:|:|:....: .|.|        |.|..||:
Mouse   265 PPPAQPSAALPSSVPATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPK--------EMLKELNQ 321

  Fly    75 LREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGV 139
            .|......|.:|.|....|.||:.::.|||.||:      :.......|.|.:.:....:.:..:
Mouse   322 QRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFK------DLIQRSVQDSSQSSREKLELVLSNL 380

  Fly   140 SSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARF 204
            .:.::..::::.|.....|..:|...||..|.........|.|..:|.:.||..||:.::..|..
Mouse   381 QADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEA 445

  Fly   205 RFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNP 269
            ....:|:..|:.:.|:.|.|||.:. :||.:|.:||.:.:|:|.|||:.|:.|::..:|||.::|
Mouse   446 MQCSELYHMAKAFALQIFPEVAAQE-EILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDP 509

  Fly   270 ESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFLNPQADELT 334
            .:|.::.|.|:..|||..:.|...:..|.....:...||.:.|:.:..::     .:.|.|.:..
Mouse   510 ATRAQYAAELLAAVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRY-----HMLPHARQEM 569

  Fly   335 TPPLAMPRLP---HEVIFAIGG--WSGGTSKG--CIETYDTRADRWVTINAEDPAGPRAYHGTAV 392
            ..|...|||.   .|||..:||  ..|.|.:.  .:..::.:.::|..: |..|...|.:.....
Mouse   570 QTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL-ASLPFYDREFFSVVS 633

  Fly   393 LGFKIFSIGGYD-GVEYFNT-CRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNR 455
            .|..|:..||.: ||...:. |  :.::...||.::.|...||..:....:|.||.:||......
Mouse   634 AGDNIYLSGGMESGVTLADVWC--YMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGN 696

  Fly   456 LNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFN-GQECLDSAEYYDPVTNVWTRI 519
            ::.||||:..||||..:.|:......|:|.....:||..||.| ........:.|.|.||.|:.|
Mouse   697 VDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFI 761

  Fly   520 PNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDPDTQTWHFIREMNHSRSNFGLEIIDDM 584
            .:..........|.....::::||  ..||.:|  .:||:.........|||||......::|..
Mouse   762 ESPMIDNKYAPAVTLNGFVFILGG--AYARATT--IYDPEKGNIKAGPNMNHSRQFCSAVVLDGK 822

  Fly   585 IFAIGGFNGVST----ISHTECYVAETDEW 610
            |:|.||.  ||:    :.:.|.|...|:.|
Mouse   823 IYATGGI--VSSEGPALGNMEAYEPTTNTW 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	15/45 (33%)
		PHA03098	86..610	CDD:222983	139/537 (26%)
		KELCH repeat	385..428	CDD:276965	10/44 (23%)
		KELCH repeat	432..475	CDD:276965	15/42 (36%)
		KELCH repeat	479..523	CDD:276965	13/44 (30%)
		KELCH repeat	526..571	CDD:276965	9/44 (20%)
		KELCH repeat	573..617	CDD:276965	12/42 (29%)
Klhl29	NP_001157965.1	PHA03247	<39..290	CDD:223021	6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..145
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..291		6/25 (24%)
		BTB_POZ	312..438	CDD:453885	32/139 (23%)
		PHA03098	333..860	CDD:222983	140/539 (26%)
		BACK_KLHL29_KBTBD9	432..533	CDD:350543	34/101 (34%)
		KELCH repeat	577..621	CDD:276965	11/44 (25%)
		Kelch 1	585..635		10/50 (20%)
		KELCH repeat	626..669	CDD:276965	10/44 (23%)
		Kelch 2	637..683		11/47 (23%)
		KELCH repeat	673..716	CDD:276965	15/42 (36%)
		Kelch 3	684..730		15/45 (33%)
		KELCH repeat	720..808	CDD:276965	21/91 (23%)
		Kelch 4	732..778		12/45 (27%)
		Kelch 5	779..821		12/45 (27%)
		KELCH repeat	811..857	CDD:276965	12/42 (29%)
		Kelch 6	822..870		10/31 (32%)