DRSC/TRiP Functional Genomics Resources

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Protein Alignment klhl10 and KLHDC8B

DIOPT Version :9

Sequence 1:NP_001015100.2 Gene:klhl10 / 3354863 FlyBaseID:FBgn0040038 Length:767 Species:Drosophila melanogaster
Sequence 2:XP_006713078.1 Gene:KLHDC8B / 200942 HGNCID:28557 Length:371 Species:Homo sapiens


Alignment Length:329 Identity:80/329 - (24%)
Similarity:125/329 - (37%) Gaps:41/329 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   336 PPLAMPRLPHEV------IFAIGGWS-GGTSKGCIETYDTRADRWVTINAEDPAGPRAYHGTAVL 393
            ||:...|:...|      :..:||.. .|......||.|..:..|:.: |..|.. ||.....||
Human    15 PPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLAL-APLPTA-RAGAAAVVL 77

  Fly   394 GFKIFSIGGYDGVEY-FNTCRVFDAVKKKWNEIAPMHCRRCYVSVTE----------LNGMIYAI 447
            |.::..:||.|.|:. ......|...:.:|...|.:......|:..|          .:||:||:
Human    78 GKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERGEWPPKEGTSDGMVYAL 142

  Fly   448 GGYDGHNRLNT-VERYNPRTNQWSVIPPMNMQRSDASACTLQERIYA-------TGGFNGQECLD 504
            ||......... |..|.||.:.|..:|.|......||......:||.       |||..|:..:.
Human   143 GGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGTPIPLTGGRQGKLPVT 207

  Fly   505 SAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGF------NGTAR---LSTGERFDPDT 560
            :.|.:|.....|||.|::..||:...|......::.:||.      |..:|   ::|.|.||.:.
Human   208 AFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYSRPHFVNTVEMFDLEH 272

  Fly   561 QTWHFI---REMNHSRSNFGLEIIDDMIFAIGGF-NGVSTISHTECYVAETDEWMEATDMNIVRS 621
            .:|..:   ..|...|::|.:..:...|.||||. |....:...|.:......|.....|...|.
Human   273 GSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTARC 337

  Fly   622 ALSA 625
            :.|:
Human   338 SCSS 341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klhl10NP_001015100.2 BTB 72..186 CDD:279045
PHA03098 86..610 CDD:222983 76/312 (24%)
BACK 195..298 CDD:285009
Kelch 347..394 CDD:128874 13/53 (25%)
KELCH repeat 385..428 CDD:276965 12/43 (28%)
Kelch 396..442 CDD:128874 9/56 (16%)
Kelch_1 431..476 CDD:279660 14/55 (25%)
KELCH repeat 432..475 CDD:276965 14/53 (26%)
KELCH repeat 479..523 CDD:276965 14/50 (28%)
Kelch 490..536 CDD:128874 15/52 (29%)
Kelch_1 525..570 CDD:279660 12/56 (21%)
KELCH repeat 526..571 CDD:276965 12/56 (21%)
Kelch_1 573..617 CDD:279660 10/44 (23%)
KELCH repeat 573..617 CDD:276965 10/44 (23%)
KLHDC8BXP_006713078.1 PRK14131 1..321 CDD:237617 76/307 (25%)
Kelch_6 20..69 CDD:290672 11/50 (22%)
KELCH repeat 21..65 CDD:276965 10/44 (23%)
Kelch_1 68..114 CDD:279660 12/46 (26%)
KELCH repeat 69..114 CDD:276965 12/44 (27%)
KELCH repeat 117..173 CDD:276965 15/55 (27%)
Kelch 139..184 CDD:128874 13/44 (30%)
KELCH repeat 175..227 CDD:276965 14/51 (27%)
Kelch 186..239 CDD:128874 15/52 (29%)
Kelch_1 228..279 CDD:279660 12/50 (24%)
KELCH repeat 229..279 CDD:276965 11/49 (22%)
Kelch_6 288..336 CDD:290672 11/47 (23%)
KELCH repeat 288..334 CDD:276965 11/45 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1072
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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