DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klhl10 and spe-26

DIOPT Version :9

Sequence 1:	NP_001015100.2	Gene:	klhl10 / 3354863	FlyBaseID:	FBgn0040038	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_501919.1	Gene:	spe-26 / 177929	WormBaseID:	WBGene00004972	Length:	570	Species:	Caenorhabditis elegans

Alignment Length:	671	Identity:	155/671 - (23%)
Similarity:	253/671 - (37%)	Gaps:	195/671 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 CD-AQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMN 145
            || |.||..|:.|.|...     .|....:.....|.:|     ...:||   |.:|..:.
Worm    15 CDVAIISKDEERFEVKLV-----ESEIARELNRLGALSP-----RSMQKN---ILVPFTTQ---- 62

  Fly   146 CVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLG-------RILTPEN--CVSIMGF 201
             .::| .|....:|:|        .|.:|..|:.|..::..|       :||..:|  |..|:.
Worm    63 -TVKY-LLGLEKVSDS--------TDEMGWFGIEKSLEEIAGFGQHCFPKILEMKNTICDHILS- 116

  Fly   202 ARFRFLED-----LHLKARNY--------TLRYFTEVAYR-----------NIDILDMSAEDFYS 242
                .|.|     ||.|.|.:        ||.|   :.|.           :::...:..|:...
Worm   117 ----TLSDVNCFLLHKKFREFDCQNHAHKTLEY---ILYNLARMVVVDKRVDVEFYRLPVEEVKH 174

  Fly   243 IISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECE 307
            ::|.:|:|..:|..:.::..:||..:.|:|.:....||:.||.                ..|:.:
Worm   175 LLSSEEVNVEQETQIIEVINQWIAADFENRDKFRPMLMSTVRF----------------LALDQQ 223

  Fly   308 AAKPLIVDTFKFMYDLDFLNPQADELTTPPLAMPRLPHEVIFAIGGWSGGTSKGCIETYDTRADR 372
            .||.|  ..|.                 |.|...|...:|:..||||....:...||.:|...:.
Worm   224 IAKSL--SQFH-----------------PSLKPARRTRDVLIIIGGWLHRQACDRIEWFDPENNC 269

  Fly   373 WVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDAVKKKW------NEIAPMHCR 431
            |.....:.|. ..||||:|::...::..||..|..  ..|..:....:.|      |.:.|
Worm   270 WKVSQQKLPT-TLAYHGSAIVDGILYLFGGSTGQR--TRCETWKLSTETWQWDRCNNMMEP---- 327

  Fly   432 RCYVSVTEL--NGMIYAIGGYDGHN------RLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQ 488
            |.|:|.:.:  :|.||..||.:...      |..|.|.::|:||:|:....::..|||.:|...:
Worm   328 RNYISNSSVVYDGRIYVFGGQNFREITRTAVRSRTGEVFDPKTNKWTETASLSDMRSDCAAEVFE 392

  Fly   489 ERIYATGGFNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLS-- 551
            .:||.:|||||...|.|.|.|:|:.||::|..::.:..:|...:...|||.::|||:|..|.:
Worm   393 NQIYVSGGFNGDMILASVEVYNPIGNVFSRTVDLPYPITGHCLLNHGNQLLIVGGFDGAERQNKI 457

  Fly   552 -----TGERFDPDTQTWHFIRE-MNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEW 610
                 |||        |....| :.:.||..........:|::.|:.                |.
Worm   458 WMWHRTGE--------WQQRPEKLIYGRSTSAACSYKGWLFSVAGYT----------------EK 498

  Fly   611 MEAT------DMNIVR--------SALSANNIAGLPNKRDYIHKERDRLMEERRQRLMATAMARE 661
            :|||      :.|..|        .|.||.|:...||.|:::         |||
Worm   499 VEATCEILLPEPNASRFSFIPDVPRAKSALNVLVAPNWRNFL---------ERR----------- 543

  Fly   662 NVGHGNASQMLVEHNDGAMDD 682
                |..::..:|.:|...||
Worm   544 ----GTINEQSMEMDDDYEDD 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB	72..186	CDD:279045	23/104 (22%)
		PHA03098	86..610	CDD:222983	131/578 (23%)
		BACK	195..298	CDD:285009	25/126 (20%)
		Kelch	347..394	CDD:128874	15/46 (33%)
		KELCH repeat	385..428	CDD:276965	11/48 (23%)
		Kelch	396..442	CDD:128874	10/53 (19%)
		Kelch_1	431..476	CDD:279660	15/52 (29%)
		KELCH repeat	432..475	CDD:276965	15/50 (30%)
		KELCH repeat	479..523	CDD:276965	19/43 (44%)
		Kelch	490..536	CDD:128874	16/45 (36%)
		Kelch_1	525..570	CDD:279660	14/52 (27%)
		KELCH repeat	526..571	CDD:276965	14/52 (27%)
		Kelch_1	573..617	CDD:279660	8/49 (16%)
		KELCH repeat	573..617	CDD:276965	8/49 (16%)
spe-26	NP_501919.1	BACK	131..223	CDD:197943	19/110 (17%)
		Kelch	244..291	CDD:128874	15/47 (32%)
		Kelch_1	282..325	CDD:279660	11/44 (25%)
		KELCH repeat	282..324	CDD:276965	10/43 (23%)
		KELCH repeat	328..380	CDD:276965	15/51 (29%)
		Kelch	341..393	CDD:128874	15/51 (29%)
		KELCH repeat	383..428	CDD:276965	19/44 (43%)
		Kelch	394..440	CDD:128874	16/45 (36%)
		KELCH repeat	430..471	CDD:276965	13/48 (27%)
		Kelch	441..487	CDD:128874	14/53 (26%)
		KELCH repeat	477..522	CDD:276965	10/60 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145100at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920