Protein Alignment klhl10 and kel-3

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_499784.2
• Gene: kel-3 / 176775
• WormBaseID: WBGene00002185
• Length: 591
• Species: Caenorhabditis elegans
• Alignment Length: 574
• Identity: 155/574 - (27%)
• Similarity: 267/574 - (46%)
• Gaps: 39/574 - (6%)

  Fly    62 PIVSDEALNTL----------------NELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQ 110
            |:.:|:.|:.:                ||||.:..|||..:.|.....:.|:.|:.:...|||..
 Worm    15 PLYTDDDLDFIKVDILDEMYKKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGM 79

  Fly   111 FTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGM 175
            ||         :|..:|......|....::...::.::.:||..:..|:.|||..:::.|::..|
 Worm    80 FT---------LDLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIMLGANFFQM 135

  Fly   176 VGLVKKCKDYLGRILTPENCVSIMGFARFRFLED-LHLKARNYTLRYFTEVAYRNIDILDMSAED 239
            :.:|:.|.::|...|.|.|.:||..|.:...:|: :.....:|..::|..|: ::.|...:|.||
 Worm   136 LEVVQHCGNFLLTRLHPSNALSIREFCKMMCVEEKITEMTDDYIQKHFMAVS-KDEDFKRLSLED 199

  Fly   240 FYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVL 304
            ...::.:|.|....|:.|:...::|::.: ..|....|.::..|||.|::|......|..:|.:.
 Worm   200 AIELLRNDHLYVDSEEQVYVAAMEWLNCD-VIRHEQAAKILPCVRLPLLSPTYLSSIVASNPIIK 263

  Fly   305 ECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLAMPRLPHEV---IFAIGG-WSGGTSKGCIET 365
            :....:.||.:...:     .|.|....|.......|||...|   |.|||| .....||..:|.
 Worm   264 KDIPCRDLIDEAKDY-----HLLPDRRSLIKSFKCTPRLCQIVPGLIVAIGGLMHQSQSKSSVEI 323

  Fly   366 YDTRADRWVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDAVKKKWNEIAPMHC 430
            ||..:.:|..|:.......|.  |.||...::::|||::|.:..:....||....||..::|:..
 Worm   324 YDPTSKKWSPIDGMVTLRTRV--GVAVNQRQVYAIGGFNGQDRLDLVEKFDYDTLKWTTLSPLTR 386

  Fly   431 RRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATG 495
            :|..::...:...:|..|||||.:.|:::|.|:...|.|...|||...||.|....:.:.||..|
 Worm   387 KRSALAAAFVTNRLYVCGGYDGLHSLSSIEIYDINRNVWEAGPPMENMRSAAGVTVIDKHIYICG 451

  Fly   496 GFNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDPDT 560
            |.:|.:...|.|..|.....|.|||:|..:|.......|:.::||.||::||:.|.:.|.:||..
 Worm   452 GHDGMQIFASVERLDTENQQWERIPSMIQQRCRFGAATFKGKIYVAGGYDGTSFLKSVEVYDPVE 516

  Fly   561 QTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEAT 614
            :.|..:..||..||...|...::.:||:.||:|.:.:...|.|...||.|..||
 Worm   517 KKWSPVSPMNMRRSRVSLVSTNEGLFAVAGFDGENNLCSMEQYDDVTDSWTIAT 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	14/61 (23%)
		PHA03098	86..610	CDD:222983	142/528 (27%)
		KELCH repeat	385..428	CDD:276965	12/42 (29%)
		KELCH repeat	432..475	CDD:276965	13/42 (31%)
		KELCH repeat	479..523	CDD:276965	15/43 (35%)
		KELCH repeat	526..571	CDD:276965	14/44 (32%)
		KELCH repeat	573..617	CDD:276965	15/42 (36%)
kel-3	NP_499784.2	BTB_POZ	32..149	CDD:453885	29/125 (23%)
		PHA03098	51..568	CDD:222983	145/534 (27%)
		KELCH repeat	341..384	CDD:276965	12/44 (27%)
		KELCH repeat	388..431	CDD:276965	13/42 (31%)
		KELCH repeat	435..479	CDD:276965	15/43 (35%)
		KELCH repeat	482..527	CDD:276965	14/44 (32%)
		KELCH repeat	529..572	CDD:276965	15/42 (36%)