Protein Alignment klhl10 and KBTBD3

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_689646.2
• Gene: KBTBD3 / 143879
• HGNCID: 22934
• Length: 612
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 146/607 - (24%)
• Similarity: 253/607 - (41%)
• Gaps: 103/607 - (16%)

  Fly    63 IVSDE----ALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVD 123
            :||::    .|:.|...||||:..|.:|.:.:::...||.::.:||.:|||.|           :
Human    29 LVSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMF-----------E 82

  Fly   124 GSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGR 188
            .:..::::..:.|..:||..:...:.|||..:|.|::.||......:.::.:..|.|.|.|:|.:
Human    83 VNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIK 147

  Fly   189 ILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTRE 253
            .:...||:.::..:.......|...|.::...:|: :.:::.|.|:|:.......:..||||..|
Human   148 SINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFS-LLFKSSDFLEMNFGVLQKCLESDELNVPE 211

  Fly   254 EDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFK 318
            |:.|.|:.:.|...|.|||::::.||:..|||..::.:...:.:.....:|:......:|:|..|
Human   212 EEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDAIK 276

  Fly   319 FMYDLDFLNPQADELTTPPLAMPRLPHEVIFAIGGWSGGTSKGCIETYDTRADRWVTINAEDPAG 383
            .:.....|.|.|...||         .:.||.......|.::... .|:.::|.|..:
Human   277 CVQGSGGLFPDARPSTT---------EKYIFIHKTEENGENQYTF-CYNIKSDSWKIL------- 324

  Fly   384 PRAY----HGTAV--LGFKIFSIGGYDGVEYFNTCRV---------FDAVKKKWNEIAPMHC--- 430
            |:::    .|:::  .|.|||..||..|    ..||.         .||..:.|     .:|
Human   325 PQSHLIDLPGSSLSSYGEKIFLTGGCKG----KCCRTVRLHIAESYHDATDQTW-----CYCPVK 380

  Fly   431 ------------RRCYVSVTELNGMIYAIGGYDGHNR----LNTVERYNPRTNQW-SVIP-PMNM 477
                        |..:.||..|: .::.|||....:|    |..||.|||.:.:| ||.| |..:
Human   381 NDFFLVSTMKTPRTMHTSVMALD-RLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGI 444

  Fly   478 QRSDASACTLQERIYATG-------GFNGQECLDSAEYYDPVTNVWTRIP---NMNHRRSGVSCV 532
            ...:||.|  |..||..|       .||  ..||....|:..|:.|:.:.   ......:.:..|
Human   445 YYPEASTC--QNVIYVLGSEVEITDAFN--PSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAV 505

  Fly   533 AFRNQLYVIGGFNGTARLSTGE--RFDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVS 595
            .....||:       ..|||.:  .|.|||..|........:..|.|...|:|.|:.:||.....
Human   506 PVNCTLYI-------CDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYAPD 563

  Fly   596 TIS-HTECYVAETDEWMEATDM 616
            .|: ..:.|.:...||.|.:.|
Human   564 EITDEVQVYHSNRSEWEEVSPM 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	14/48 (29%)
		PHA03098	86..610	CDD:222983	133/572 (23%)
		KELCH repeat	385..428	CDD:276965	13/57 (23%)
		KELCH repeat	432..475	CDD:276965	17/48 (35%)
		KELCH repeat	479..523	CDD:276965	14/53 (26%)
		KELCH repeat	526..571	CDD:276965	11/46 (24%)
		KELCH repeat	573..617	CDD:276965	13/45 (29%)
KBTBD3	NP_689646.2	BTB_POZ_KBTBD3_BKLHD3	28..157	CDD:349580	35/138 (25%)
		PHA03098	56..586	CDD:222983	137/580 (24%)
		BACK_KBTBD3	149..230	CDD:350555	19/81 (23%)
		Kelch 1. /evidence=ECO:0000255	295..341		8/53 (15%)
		KELCH repeat	334..389	CDD:276965	14/63 (22%)
		Kelch 2. /evidence=ECO:0000255	343..403		15/68 (22%)
		KELCH repeat	393..441	CDD:276965	18/48 (38%)
		Kelch 3. /evidence=ECO:0000255	404..454		18/51 (35%)
		KELCH repeat	444..489	CDD:276965	14/48 (29%)
		Kelch 4. /evidence=ECO:0000255	456..506		10/51 (20%)
		KELCH repeat	541..586	CDD:276965	13/45 (29%)
		Kelch 5. /evidence=ECO:0000255	552..599		9/34 (26%)