Protein Alignment klhl10 and KLHL40

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_689606.2
• Gene: KLHL40 / 131377
• HGNCID: 30372
• Length: 621
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 144/607 - (23%)
• Similarity: 238/607 - (39%)
• Gaps: 132/607 - (21%)

  Fly    72 LNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHI 136
            |.::.:.....|..:..||..|..||.::.:||.||||:|..             ..:....:|:
Human    23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLA-------------EPERAGELHL 74

  Fly   137 PGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGF 201
            ..||..::..|:.|.|..:..:.|::|.:|...|....:..:...|..:|.:.|...||:::.
Human    75 EEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVF-- 137

  Fly   202 ARFRFLED---LHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVK 263
             |...|.|   |.:.||::...:||.|| |:.|.|.:||::..:|||.|.||..:|:.|::..::
Human   138 -RLGLLLDCARLAVAARDFICAHFTLVA-RDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMR 200

  Fly   264 WI---DRNPES-RKRHVAHLMTGVRLGLMTPKCFME-EVKEHPYVL------------------- 304
            |.   |...:: |:|.:..:...||..|: |:.|:| .|:.||.|.
Human   201 WAGSGDAEAQAERQRALPTVFESVRCRLL-PRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGR 264

  Fly   305 --------------------------------ECEAAKP-LIVDTFK---FMYDLDFL------- 326
                                            |.|...| ::.||.:   |:.||.|:
Human   265 ITTLRKKKKGKDGAGAKEADKGTSKAKAEEDEEAERILPGILNDTLRFGMFLQDLIFMISEEGAV 329

  Fly   327 --NPQADELTTPPLA--MPR------LPHEVIFAIGG--WSGGTSKGCIETYDTRAD----RWVT 375
              :|.|:|.....|:  :|:      .....:|..||  ::....:..:..|..:.|    .|
Human   330 AYDPAANECYCASLSNQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEW-- 392

  Fly   376 INAEDPAGPRAYHGTAVLGFKIFSIGG---YDGVEYFNTCRVFDAVKKKWNEIAPMHCRRCYV-- 435
            :.......||...|.......|:.:||   .||....::...:|.:..||.|..|:.    ||
Human   393 LGMPPLPSPRCLFGLGEALNSIYVVGGREIKDGERCLDSVMCYDRLSFKWGESDPLP----YVVY 453

  Fly   436 --SVTELNGMIYAIGGYDGHNR--LNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGG 496
              :|.....::|.||| .|.:|  ||.:..|:|:..:|..:.||...||...|.....||....|
Human   454 GHTVLSHMDLVYVIGG-KGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAG 517

  Fly   497 FNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGE------- 554
            ........|||.|....|.|.........||.:|.|:....||.|||| .|....:||
Human   518 VTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLSLVSLVGTLYAIGGF-ATLETESGELVPTELN 581

  Fly   555 ---RFDPDTQTWH-FIREMNHS 572
               |::.:.:.|. .:||:.::
Human   582 DIWRYNEEEKKWEGVLREIAYA 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	10/35 (29%)
		PHA03098	86..610	CDD:222983	142/593 (24%)
		KELCH repeat	385..428	CDD:276965	11/45 (24%)
		KELCH repeat	432..475	CDD:276965	14/48 (29%)
		KELCH repeat	479..523	CDD:276965	12/43 (28%)
		KELCH repeat	526..571	CDD:276965	17/55 (31%)
		KELCH repeat	573..617	CDD:276965	144/607 (24%)
KLHL40	NP_689606.2	BTB_POZ_KLHL40_KBTBD5	6..137	CDD:349649	29/126 (23%)
		PHA03098	47..551	CDD:222983	124/528 (23%)
		BACK	128..230	CDD:475122	33/106 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	265..295		0/29 (0%)
		KELCH repeat	351..398	CDD:276965	6/48 (13%)
		Kelch 1	360..412		9/53 (17%)
		KELCH repeat	402..448	CDD:276965	11/45 (24%)
		Kelch 2	413..462		13/52 (25%)
		KELCH repeat	452..497	CDD:276965	13/45 (29%)
		Kelch 3	463..510		16/47 (34%)
		Kelch 4	512..557		12/44 (27%)
		Kelch_1	547..594	CDD:396078	14/47 (30%)
		KELCH repeat	547..594	CDD:276965	14/47 (30%)
		Kelch 5	559..613		13/46 (28%)