DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment klhl10 and KLHL33

DIOPT Version :9

Sequence 1:NP_001015100.2 Gene:klhl10 / 3354863 FlyBaseID:FBgn0040038 Length:767 Species:Drosophila melanogaster
Sequence 2:NP_001352719.1 Gene:KLHL33 / 123103 HGNCID:31952 Length:797 Species:Homo sapiens


Alignment Length:670 Identity:156/670 - (23%)
Similarity:252/670 - (37%) Gaps:165/670 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 LREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTG-------FNAD-TPG--------CVD 123
            ||||.||.|.::||...|:.|||.|:.:.||.||.:..|       |:.: :||        ..:
Human   106 LREQRLLLDEEVSVAGRVYGVHRVILAAISSLFRDRLLGGGGPRPPFSLEVSPGGWEAVLTFAYE 170

  Fly   124 G-------------------------------------SDAKKNN------------NFIHIPGV 139
            |                                     .|.||.:            ..::..||
Human   171 GVLGPASQGDVLAAAEALGAPRVKAAAQQTCERAGNAREDVKKPSQAEELRENLRGIELLYREGV 235

  Fly   140 --------SSCIMN-------CVIQY------AYLRQTNISESNVH-------ELLICADYVGMV 176
                    ..|.::       |..::      :.:|::..:|.::.       .||:...|.|:|
Human   236 GCDLKLEAGGCQLSVHRAALACGSEFFGAMLLSGMRESQGTEVSLRTISTQDLRLLVSFAYSGVV 300

  Fly   177 -----GLVKK---------------CKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRY 221
                 ||::.               |:..|.|.|:|..|:::...|....||.|..|||:|.|.:
Human   301 RARWPGLLRAAQAALQYQSSSCLDLCQKGLARGLSPARCLALFPMAEAPGLERLWSKARHYLLTH 365

  Fly   222 FTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLG 286
            ...||.... ...:.|.....::..|||:.:||...:.....|:..|||:::.....|:..||.|
Human   366 LPAVALCPA-FPSLPAACLAELLDSDELHVQEEFEAFVAARCWLAANPETQESEAKALLRCVRFG 429

  Fly   287 LMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLAMPRLPHEVIFAI 351
            .|:       .:|...|.......||..|.      |..|..:||   .|.....|.|...:..|
Human   430 RMS-------TRELRRVRAAGLLPPLTPDL------LHQLMVEAD---VPGQERRREPDRALVVI 478

  Fly   352 GG-----------------WSGG--TSKGCIETYDTRADRWVTINAEDPAGPRAYHGTAVL-GFK 396
            ||                 |:..  ...|.:.|.:     |..:.|. ||..|..||.|.| |.:
Human   479 GGDGLRPDMALRQPSRAVWWARAFRCGVGLVRTVE-----WGQLPAL-PAPGRFRHGAASLAGSE 537

  Fly   397 IFSIGGYDGVEYFNTCRV---FDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNT 458
            ::..||.|...:.||...   ::..::.|.|:||:...|...|:..|:|.:||:||......|::
Human   538 LYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHNDVALDS 602

  Fly   459 VERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNGQ-ECLDSAEYYDP-VTNVWTRIPN 521
            ||.|||..|.|...|.:.......:|..|:.::|.:||..|. :.|.|..:||| :....|.:..
Human   603 VETYNPELNVWRPAPALPAPCFAHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSP 667

  Fly   522 MNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDPDTQTWHFIREMNHSRSNFGLEIIDDMIF 586
            |...|:|....|...:|||.||...|..|.:.|.::..|.:|..:..:..........::...:.
Human   668 MGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASAVLQGELL 732

  Fly   587 AIGGFN----GVSTISHTEC 602
            .:||::    .:|.:.|..|
Human   733 VLGGYSHRTYALSHLIHAYC 752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klhl10NP_001015100.2 BTB 72..186 CDD:279045 40/223 (18%)
PHA03098 86..610 CDD:222983 149/659 (23%)
BACK 195..298 CDD:285009 27/102 (26%)
Kelch 347..394 CDD:128874 15/66 (23%)
KELCH repeat 385..428 CDD:276965 14/46 (30%)
Kelch 396..442 CDD:128874 12/48 (25%)
Kelch_1 431..476 CDD:279660 17/44 (39%)
KELCH repeat 432..475 CDD:276965 17/42 (40%)
KELCH repeat 479..523 CDD:276965 12/45 (27%)
Kelch 490..536 CDD:128874 14/47 (30%)
Kelch_1 525..570 CDD:279660 13/44 (30%)
KELCH repeat 526..571 CDD:276965 13/44 (30%)
Kelch_1 573..617 CDD:279660 5/34 (15%)
KELCH repeat 573..617 CDD:276965 5/34 (15%)
KLHL33NP_001352719.1 BTB 104..203 CDD:321966 23/96 (24%)
BTB 230..>298 CDD:321966 9/67 (13%)
BACK 339..439 CDD:197943 28/107 (26%)
KELCH repeat 525..574 CDD:276965 15/48 (31%)
BTB <538..742 CDD:333434 54/203 (27%)
KELCH repeat 576..619 CDD:276965 17/42 (40%)
KELCH repeat 623..669 CDD:276965 12/45 (27%)
KELCH repeat 672..717 CDD:276965 13/44 (30%)
KELCH repeat 719..765 CDD:276965 5/34 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1072
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.