DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment klhl10 and KLHL32

DIOPT Version :9

Sequence 1:	NP_001015100.2	Gene:	klhl10 / 3354863	FlyBaseID:	FBgn0040038	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_001310181.1	Gene:	KLHL32 / 114792	HGNCID:	21221	Length:	620	Species:	Homo sapiens

Alignment Length:	601	Identity:	148/601 - (24%)
Similarity:	262/601 - (43%)	Gaps:	94/601 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PEDKTLGI-----GRKTILNAHTKSLAPIVSDEALNTLNELREQNLLCDAQISVGEDVFNVHRAI 99
            |.::.|.|     |::.   .|::|    .:|..|..||:.|...:|||..:...|..|:.|:|:
Human     2 PSERCLSIQEMLTGQRL---CHSES----HNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAV 59

  Fly   100 MCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVH 164
            :.:||.||||.|:       .|:..|.|.:    :::.||:|..:...:::||..|..:....:.
Human    60 LAACSDYFRAMFS-------LCMVESGADE----VNLHGVTSLGLKQALEFAYTGQILLEPGVIQ 113

  Fly   165 ELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTE-VAYR 228
            ::|....::.::.|:..|..||.:.|...|.:.:...|....|..|.....::.:::.:| :..|
Human   114 DVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSR 178

  Fly   229 NIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCF 293
            ..::|.:.......::..|.|.:..|:.:|:|.|:|::.|  ...:::..|:..:|.|||.....
Human   179 PEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHN--CHYQYMDELLQYIRFGLMDVDTL 241

  Fly   294 MEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLAMPRLPHEVIFAIGGWSGGT 358
            ......||.|...|.|..|:.:..::...: :..|......|    .||...:.::.|||.....
Human   242 HTVALSHPLVQASETATALVNEALEYHQSI-YAQPVWQTRRT----KPRFQSDTLYIIGGKKREV 301

  Fly   359 SKGCIETYDTRADR----------WVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFN--T 411
            .|.....|....|:          |..: |..|.| |::|..||:|..:|..||  .||:.:  |
Human   302 CKVKELRYFNPVDQENALIAAIANWSEL-APMPVG-RSHHCVAVMGDFLFVAGG--EVEHASGRT 362

  Fly   412 CRV-----FDAVKKKWNEIAPM-HCRRCYVSVTELNGMIYAIGGYDGHNRLN----TVERYNPRT 466
            |.|     :|.....|.||||| :||..:| :..:...:||:|   |.|.|.    |||||.|:.
Human   363 CAVRTACRYDPRSNSWAEIAPMKNCREHFV-LGAMEEYLYAVG---GRNELRQVLPTVERYCPKK 423

  Fly   467 NQWSVIPPMNMQRSDASACTLQERIYATGGFNGQECLDSAEY------YDPVTNVWTRIPNMNHR 525
            |:|:.:...:...|..:.......::.:||..     ::|:|      |:|..|.|.....|..|
Human   424 NKWTFVQSFDRSLSCHAGYVADGLLWISGGVT-----NTAQYQNRLMVYEPNQNKWISRSPMLQR 483

  Fly   526 RSGVSCVAFRNQLYVIGG----FNGTARLSTG-ERFDPDTQTWHFIREMNHSRSNF--------- 576
            |...|..|.:.:|||:||    :|....|... :.::.||..|        :|.||
Human   484 RVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQW--------TRCNFNLLTGQNES 540

  Fly   577 GLEIIDDMIFAIGGFN 592
            |:.:.:..|:.:||::
Human   541 GVAVHNGRIYLVGGYS 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB	72..186	CDD:279045	29/113 (26%)
		PHA03098	86..610	CDD:222983	134/550 (24%)
		BACK	195..298	CDD:285009	19/103 (18%)
		Kelch	347..394	CDD:128874	14/56 (25%)
		KELCH repeat	385..428	CDD:276965	18/49 (37%)
		Kelch	396..442	CDD:128874	18/53 (34%)
		Kelch_1	431..476	CDD:279660	16/48 (33%)
		KELCH repeat	432..475	CDD:276965	15/46 (33%)
		KELCH repeat	479..523	CDD:276965	9/49 (18%)
		Kelch	490..536	CDD:128874	13/51 (25%)
		Kelch_1	525..570	CDD:279660	14/49 (29%)
		KELCH repeat	526..571	CDD:276965	13/49 (27%)
		Kelch_1	573..617	CDD:279660	7/29 (24%)
		KELCH repeat	573..617	CDD:276965	7/29 (24%)
KLHL32	NP_001310181.1	PHA03098	30..590	CDD:222983	140/566 (25%)
		BTB	32..136	CDD:279045	30/114 (26%)
		BACK	144..244	CDD:197943	19/101 (19%)
		Kelch 1	290..346		14/57 (25%)
		Kelch	291..346	CDD:128874	14/56 (25%)
		Kelch_6	336..388	CDD:290672	20/53 (38%)
		KELCH repeat	336..384	CDD:276965	18/49 (37%)
		Kelch 2	347..398		18/53 (34%)
		KELCH repeat	388..433	CDD:276965	16/48 (33%)
		Kelch_1	388..431	CDD:279660	16/46 (35%)
		Kelch 3	399..446		15/49 (31%)
		KELCH repeat	436..482	CDD:276965	10/50 (20%)
		Kelch 4	447..494		13/51 (25%)
		Kelch	447..493	CDD:128874	13/50 (26%)
		Kelch_1	483..529	CDD:279660	14/53 (26%)
		KELCH repeat	484..534	CDD:276965	16/57 (28%)
		Kelch 5	496..547		14/58 (24%)
		Kelch 6	549..599		3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810