DRSC/TRiP Functional Genomics Resources

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Protein Alignment klhl10 and KLHL2

DIOPT Version :10

Sequence 1:NP_001015100.2 Gene:klhl10 / 3354863 FlyBaseID:FBgn0040038 Length:767 Species:Drosophila melanogaster
Sequence 2:XP_047305516.1 Gene:KLHL2 / 11275 HGNCID:6353 Length:675 Species:Homo sapiens


Alignment Length:616 Identity:186/616 - (30%)
Similarity:303/616 - (49%) Gaps:60/616 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 MDSLQLNADGNSPEDKTLGIGRKTILNAHTKSLAPIVSDEALNTLNELREQNLLCDAQISVGEDV 92
            :||...|.:.:.|         .|:...|.|        :|...:||||.||||||..| |.||:
Human   101 LDSKDDNTEKHCP---------VTVNPWHMK--------KAFKVMNELRSQNLLCDVTI-VAEDM 147

  Fly    93 -FNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQT 156
             .:.||.::.:||.||.|.|||..::       |.||:    :.|..|....:..:|.|.|..:.
Human   148 EISAHRVVLAACSPYFHAMFTGEMSE-------SRAKR----VRIKEVDGWTLRMLIDYVYTAEI 201

  Fly   157 NISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRY 221
            .::|.||..||..|..:.:..:.|.|.::|...|.|.||:.|..||......||..||..|..::
Human   202 QVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQH 266

  Fly   222 FTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLG 286
            |.:|.... :.|::..|...|:||.|:|....|:.|::..:.|::.:.:.|:..:|.||..|||.
Human   267 FADVVLSE-EFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLP 330

  Fly   287 LMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFLNPQADEL--------TTPPLAMPRL 343
            |:..:..::.|:|...|....|.|..:::..|:     .|.|....:        ...|:.:|:|
Human   331 LLPREYLVQRVEEEALVKNSSACKDYLIEAMKY-----HLLPTEQRILMKSVRTRLRTPMNLPKL 390

  Fly   344 PHEVIFAIGGWSGGTSKGCIETYDTRADRWVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEY 408
                :..:||.:....:. :|.||.:.:||..: ||.|: .|...|...:...:|::||::|...
Human   391 ----MVVVGGQAPKAIRS-VECYDFKEERWHQV-AELPS-RRCRAGMVYMAGLVFAVGGFNGSLR 448

  Fly   409 FNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIP 473
            ..|...:|.||.:|..:|.|..||..:....|||::||:||:||...|::||.||.::|:|..:.
Human   449 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVA 513

  Fly   474 PMNMQRSDASACTLQERIYATGGFNG--QECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRN 536
            |||.:||......:...:||.||::|  ::||.:.|.|:..||.||.|..|:.||||.......|
Human   514 PMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNN 578

  Fly   537 QLYVIGGFNGTARLSTGERFDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTE 601
            .||.:||.:|.....:.|.:||.|..|..:.:||..|.|.|:..::.:::.:||.:|...::..|
Human   579 LLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVE 643

  Fly   602 CYVAETDEWMEATDMNIVRSALS-ANNIAGL 631
            .|...||:|      .:|.|.:| ..:.||:
Human   644 YYNPTTDKW------TVVSSCMSTGRSYAGV 668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klhl10NP_001015100.2 BTB_POZ 62..>108 CDD:453885 20/46 (43%)
PHA03098 86..610 CDD:222983 162/534 (30%)
KELCH repeat 385..428 CDD:276965 12/42 (29%)
KELCH repeat 432..475 CDD:276965 17/42 (40%)
KELCH repeat 479..523 CDD:276965 16/45 (36%)
KELCH repeat 526..571 CDD:276965 15/44 (34%)
KELCH repeat 573..617 CDD:276965 11/43 (26%)
KLHL2XP_047305516.1 BTB_POZ_KLHL2_Mayven 117..237 CDD:349647 45/139 (32%)
PHA03098 138..655 CDD:222983 165/547 (30%)
BACK_KLHL2_Mayven 235..364 CDD:350587 38/134 (28%)
KELCH repeat 425..468 CDD:276965 12/42 (29%)
KELCH repeat 472..516 CDD:276965 18/43 (42%)
KELCH repeat 568..612 CDD:276965 14/43 (33%)
KELCH repeat 615..661 CDD:276965 13/51 (25%)

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