Protein Alignment klhl10 and KLHL41

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_006054.2
• Gene: KLHL41 / 10324
• HGNCID: 16905
• Length: 606
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 142/591 - (24%)
• Similarity: 242/591 - (40%)
• Gaps: 115/591 - (19%)

  Fly    72 LNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHI 136
            |.:|.::....|..:..|:.....||.|:.:||.|||..|..         :..:|||..  :.:
Human    23 LKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLS---------EIDEAKKKE--VVL 76

  Fly   137 PGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGF 201
            ..|...|::.:|:|.|....::::.||.::...|....:..:...|..||.:.|.|.||::|:
Human    77 DNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAIL-- 139

  Fly   202 ARFRFLED---LHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVK 263
             |...|.|   |.:.||.:....|.::. :..|.:.:|.::..|:||:|.||..:|:.|::..:|
Human   140 -RLGLLLDCPRLAISAREFVSDRFVQIC-KEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMK 202

  Fly   264 WIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEV------KEHP------YVLE----------- 305
            |:..:.|:|.::::.:...:|..|||.|.|.:.|      |.:|      .||:
Human   203 WVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPS 267

  Fly   306 CEAAKP----------------------------------LIVDTFKFMYDLDFLNPQADELTTP 336
            ..|||.                                  |:.||....||     |..:|....
Human   268 KNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYD-----PTENECYLT 327

  Fly   337 PLA--MPRLPHEV------IFAIGG-WSGGTSKG-CIETY----DTRADRWVTINAEDPAGP--R 385
            .||  :||....:      |:.:|| :....:|. .:::|    |:.|..||.:    |..|  |
Human   328 ALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGL----PPLPSAR 388

  Fly   386 AYHGTAVLGFKIFSIGGYD--GVEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIG 448
            ...|...:..||:.:.|.|  .....::...:|.|..||||:..:..:....:|....||||.:|
Human   389 CLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLG 453

  Fly   449 G-YDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNGQECLDSAEYYDPV 512
            | .|.....|.|..:||:...|..:.||.:.||.......:.:|...||........|.|.:|..
Human   454 GKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLT 518

  Fly   513 TNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGE----------RFDPDTQTW-HFI 566
            ||.|..:......||.:|.|:....||.|||| ...:|.:.|          :::.|.:.| ..:
Human   519 TNKWDVMTEFPQERSSISLVSLAGSLYAIGGF-AMIQLESKEFAPTEVNDIWKYEDDKKEWAGML 582

  Fly   567 REMNHS 572
            :|:.::
Human   583 KEIRYA 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	10/35 (29%)
		PHA03098	86..610	CDD:222983	139/577 (24%)
		KELCH repeat	385..428	CDD:276965	12/44 (27%)
		KELCH repeat	432..475	CDD:276965	13/43 (30%)
		KELCH repeat	479..523	CDD:276965	11/43 (26%)
		KELCH repeat	526..571	CDD:276965	15/55 (27%)
		KELCH repeat	573..617	CDD:276965	142/591 (24%)
KLHL41	NP_006054.2	BTB_POZ_KLHL41_KBTBD10	6..135	CDD:349650	29/122 (24%)
		PHA03098	39..578	CDD:222983	137/563 (24%)
		KELCH repeat	335..384	CDD:276965	11/52 (21%)
		Kelch 1	346..398		13/55 (24%)
		KELCH repeat	388..433	CDD:276965	12/44 (27%)
		Kelch 2	399..447		11/47 (23%)
		KELCH repeat	437..482	CDD:276965	14/44 (32%)
		Kelch 3	448..495		15/46 (33%)
		KELCH repeat	485..530	CDD:276965	11/44 (25%)
		Kelch 4	497..542		13/44 (30%)
		Kelch 5	544..599		11/46 (24%)