DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment klhl10 and klhl10

DIOPT Version :9

Sequence 1:	NP_001015100.2	Gene:	klhl10 / 3354863	FlyBaseID:	FBgn0040038	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	XP_012810304.1	Gene:	klhl10 / 100486163	XenbaseID:	XB-GENE-6047527	Length:	609	Species:	Xenopus tropicalis

Alignment Length:	633	Identity:	240/633 - (37%)
Similarity:	357/633 - (56%)	Gaps:	47/633 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 TLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIH 135
            ||..||::..|||.::|.|...|:.|:.|:|.||||||..|||         ..||..::..:
Frog    24 TLERLRQEGRLCDVELSAGGATFSAHKIILCGCSSYFRQLFTG---------SWSDPMRSRYW-- 77

  Fly   136 IPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMG 200
            |||:|..::..::.:||.....::..|..||.:.||...::|:.:.|..::|..|.|:||:.:..
Frog    78 IPGLSPEMLRLILDFAYTGAVGVTADNAEELFVAADQFSVMGVARACVAFMGSQLCPQNCLGMWR 142

  Fly   201 FARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWI 265
            |:.:....:|..:|.::.||:|.:|...:.:....:.::...||..|:||.::|:.:::|.|:||
Frog   143 FSAYYPCPELRQRAHSFLLRHFQQVGAESPEFRTAAPQELAEIIGSDQLNVQQEEALFQLIVQWI 207

  Fly   266 DRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFLNPQA 330
            ...||:|:..:::|:..|||.||.....:..|::|.||...|..:.|:....:..|.||...|.|
Frog   208 KMEPETRRDAISNLLPKVRLALMNTDYLLNTVQDHEYVAHSEPCQSLVTHALRLRYGLDMNGPSA 272

  Fly   331 DELTTPPLAMPRLPHEVIFAIGGWSGGTSKGCIETYDTRADRWVTINAEDPAGPRAYHGTAVLGF 395
            .:... ||..||||:.::||||||||.:....||.||.|||||..:...   .||||||...||.
Frog   273 FDFHN-PLTRPRLPYNILFAIGGWSGRSPTSAIEVYDERADRWAELEGH---SPRAYHGAVFLGN 333

  Fly   396 KIFSIGGYDGVEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVE 460
            .|:.:||:|..:||||.|.|...:::|.|::|||.||||:||..|:|.|||:||:||:.||||.|
Frog   334 FIYVLGGFDSADYFNTVRRFSLAQRRWEEVSPMHTRRCYLSVAVLHGYIYAMGGFDGYVRLNTAE 398

  Fly   461 RYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNGQECLDSAEYYDPVTNVWTRIPNMNHR 525
            ||.|.|||||:|..|:.|||||||..|..::|..|||||.|||.:||.|.|.||.|:.|..|..|
Frog   399 RYQPHTNQWSLISTMHEQRSDASATVLHGKVYICGGFNGNECLPTAEVYSPDTNQWSLIAPMGSR 463

  Fly   526 RSGVSCVAFRNQLYVIGGFNGTARLSTGERFDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGG 590
            ||||..|.|..|::.:|||:||.||::.|.:.|:|.||.....|.::|||||:|::...:|.:||
Frog   464 RSGVGVVTFLEQIFAVGGFDGTERLNSAECYAPNTNTWSQAPPMFNTRSNFGIEVLAKRLFVLGG 528

  Fly   591 FNGVSTISHTECYVAETDEWMEATDMNIVRSALSANNIAGLPNKRDYIHKERDRLMEERRQRLMA 655
            |||.:|..:.|....:.:||.:|.||.|.|||||...:.|.|:..|::.:...
Frog   529 FNGATTTCNAEYLDGDANEWFDAADMGIFRSALSCCVVPGGPDVWDFLQRPDP------------ 581

  Fly   656 TAMARENVGHGNASQMLVEHNDGAMDDYESPDEVDETDEQEQSARISR 703
                 :...|..:||             .:|.  |.|.:.|.|.|.|:
Frog   582 -----QQPSHAPSSQ-------------ATPS--DSTIQSEHSTRSSQ 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB	72..186	CDD:279045	36/113 (32%)
		PHA03098	86..610	CDD:222983	209/523 (40%)
		BACK	195..298	CDD:285009	27/102 (26%)
		Kelch	347..394	CDD:128874	23/46 (50%)
		KELCH repeat	385..428	CDD:276965	19/42 (45%)
		Kelch	396..442	CDD:128874	22/45 (49%)
		Kelch_1	431..476	CDD:279660	29/44 (66%)
		KELCH repeat	432..475	CDD:276965	28/42 (67%)
		KELCH repeat	479..523	CDD:276965	24/43 (56%)
		Kelch	490..536	CDD:128874	25/45 (56%)
		Kelch_1	525..570	CDD:279660	20/44 (45%)
		KELCH repeat	526..571	CDD:276965	20/44 (45%)
		Kelch_1	573..617	CDD:279660	18/43 (42%)
		KELCH repeat	573..617	CDD:276965	18/43 (42%)
klhl10	XP_012810304.1	PHA03098	32..566	CDD:222983	214/533 (40%)
		KELCH repeat	323..366	CDD:276965	20/42 (48%)
		KELCH repeat	370..413	CDD:276965	24/42 (57%)
		KELCH repeat	417..461	CDD:276965	26/43 (60%)
		KELCH repeat	464..507	CDD:276965	21/42 (50%)
		KELCH repeat	511..554	CDD:276965	18/42 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12018
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45628
OrthoDB	1	1.010	-	-		D145100at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5079
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060