DRSC/TRiP Functional Genomics Resources

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Protein Alignment klhl10 and klhl12

DIOPT Version :10

Sequence 1:NP_001015100.2 Gene:klhl10 / 3354863 FlyBaseID:FBgn0040038 Length:767 Species:Drosophila melanogaster
Sequence 2:NP_001106569.1 Gene:klhl12 / 100127776 XenbaseID:XB-GENE-961995 Length:320 Species:Xenopus tropicalis


Alignment Length:340 Identity:92/340 - (27%)
Similarity:157/340 - (46%) Gaps:41/340 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 SPEDKTLGIGRKTILNAHTKSLAPIVSDEALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSC 103
            :|:|        .:.|:|.||:        |||:|.||:...|||..:.|....|..||.::.:|
 Frog     2 APKD--------IMTNSHAKSI--------LNTMNSLRKSQTLCDVTLRVNLKDFPAHRIVLAAC 50

  Fly   104 SSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLI 168
            |.||.|.||           ...::|...::.|.|::|..|..::.:.|....:::..||.|||.
 Frog    51 SDYFCAMFT-----------NELSEKGKPYVDIQGLTSSTMEILLDFVYTETVHVTVENVQELLP 104

  Fly   169 CADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDIL 233
            .|..:.:.|:.:.|.|:|...|.|.||:.|..||......||...|..|:.::|.||. ::.:.:
 Frog   105 AACLLQLKGVKQACCDFLESQLDPSNCLGIRDFAETHNCLDLMQAAEVYSQKHFPEVV-QHEEFM 168

  Fly   234 DMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVK 298
            .:..|:...:|..||:....|:.|::..:.|:..|...|::.:..|:..||:.|:||:...:.:.
 Frog   169 LLHQEEVEKLIHCDEIQINSEEPVFEAVINWVKHNKNEREKSLPQLLQYVRMPLLTPRYITDVID 233

  Fly   299 EHPYV---LECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLAMPRL-PHEVIFAIGGWSGGTS 359
            ..|.:   |:|   :.|:.:..||     .|.|:.......|....|| .:||:..|||:....|
 Frog   234 AEPLIRCSLQC---RDLVDEAKKF-----HLRPELRSQMQGPRTRVRLGANEVLLVIGGFGSQQS 290

  Fly   360 K-GCIETYDTRADRW 373
            . ..:|.||.:...|
 Frog   291 PIDIVEKYDPKTQEW 305

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klhl10NP_001015100.2 BTB_POZ 62..>108 CDD:453885 16/45 (36%)
PHA03098 86..610 CDD:222983 77/293 (26%)
KELCH repeat 385..428 CDD:276965
KELCH repeat 432..475 CDD:276965
KELCH repeat 479..523 CDD:276965
KELCH repeat 526..571 CDD:276965
KELCH repeat 573..617 CDD:276965
klhl12NP_001106569.1 BTB_POZ_KLHL12_C3IP1_DKIR 8..131 CDD:349551 42/141 (30%)
BACK_KLHL12 126..261 CDD:350527 37/143 (26%)
Kelch_1 267..309 CDD:396078 13/39 (33%)
KELCH repeat 268..309 CDD:276965 12/38 (32%)
Blue background indicates that the domain is not in the aligned region.

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