DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15408 and VBA1

DIOPT Version :9

Sequence 1:	NP_608767.1	Gene:	CG15408 / 33548	FlyBaseID:	FBgn0031523	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_013806.1	Gene:	VBA1 / 855113	SGDID:	S000004694	Length:	562	Species:	Saccharomyces cerevisiae

Alignment Length:	501	Identity:	111/501 - (22%)
Similarity:	174/501 - (34%)	Gaps:	142/501 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 WLSPTLRKLQSDSPAGF--EVKSEFEIS----WVGSMLGMGSVTGNILIGCLLGRLGSKRCLLLI 98
            ||...|..|.|...|..  .|..||..|    |:.:...:.:.....|.|.|....|.|..||..
Yeast    43 WLGSFLSSLDSTIVANIMNRVAEEFSESSKKQWIATSFLLTNTAFQPLYGKLSDITGRKSALLTA 107

  Fly    99 AIPHSCFWILVYFAQSVEYLYVGRLLAGICGGGMYIVHPILLSEIADANIRGTFSAMVMLSVNVG 163
            ........:|..||::|....:.|.:.||..||:..:..|.:|:|..|..||.:.....:....|
Yeast   108 QFFFGLGCLLTCFARNVTEFSIARAICGIGAGGLNAISSIAVSDICTARERGVYQGYANIVFGFG 172

  Fly   164 ILVGYIIG-----------------------------------THLP----YYSIPLMVLI---- 185
            .|:|..:|                                   .|:|    .|::..:..|
Yeast   173 QLLGAPLGGVFIETIGWRALFGIQVPVIMLCSVLAIKNINIKLFHVPPMKERYTLKNLSRIDIFG 237

  Fly   186 -LPLWYLISVLLFIKESPMH-----LIRIGKYSAAERSFRYYKNIKDSDNIHDQNRAMEEFEIMK 244
             |.|...||.:||:..|.::     |..||.:.......|||...|           :..||:
Yeast   238 SLSLVATISGVLFLCSSQLNKLYLALFTIGSFIVFILVERYYATEK-----------ILPFEL-- 289

  Fly   245 IALTKGDALQDAVT-------FKDFYSRPALKAYGPALVLL--IANQFSGLFTMVNYMSDIFANS 300
              ||:...|..|||       |.:.:..|..      |.||  |:...:|||.:   ...|....
Yeast   290 --LTRSFCLSSAVTVISSFVVFGEIFRSPIY------LQLLQNISVTKTGLFLI---FPSISVAV 343

  Fly   301 GSTMDPDTCTIIIGAVQILGTYVTTLLCD---ICGRKLLMLVSTGGVAISLTAFGFFTKYAESHN 362
            ||        ::.|.| :..|.:....|.   |.|..::.|:..|        .|:|..   ||.
Yeast   344 GS--------LVTGWV-LRNTKINLAHCAYQIIFGGMIMQLLGLG--------LGYFLL---SHL 388

  Fly   363 IGEYS---------------WIPLLLM--SMDIFLGNIGLVGCFFVSLVEMFPVKIRAKAASMAI 410
            ..:|:               |..|:.:  |:.:..|...|:....||:|  |.|: :::..:|.
Yeast   389 NPDYTIYDMLESITFRSNSIWWKLIYVFASVLVSFGYACLLVATLVSIV--FTVE-KSQQGTMT- 449

  Fly   411 VVCSIFVFLMLNIFPICMKQWGISATMWSCAGVTALSSLYFTYFMK 456
               .:| :|..:|..:.    |.|.|:.|..  .:|||:.:.|..|
Yeast   450 ---GVF-YLWRSIGNVL----GASLTLVSYE--NSLSSMLWNYMFK 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15408	NP_608767.1	2A0115	17..410	CDD:273327	99/453 (22%)
CG15408	NP_608767.1	MFS	60..455	CDD:119392	103/476 (22%)
VBA1	NP_013806.1	MFS_Azr1_MDR_like	42..469	CDD:341045	105/481 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900