DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15408 and ATR1

DIOPT Version :9

Sequence 1:	NP_608767.1	Gene:	CG15408 / 33548	FlyBaseID:	FBgn0031523	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_013591.1	Gene:	ATR1 / 854924	SGDID:	S000004584	Length:	542	Species:	Saccharomyces cerevisiae

Alignment Length:	529	Identity:	117/529 - (22%)
Similarity:	179/529 - (33%)	Gaps:	176/529 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FQRPNCLLNRRNRYQLLTTLLINVISISHGIGIGWLSPTL--RKLQSDSPAGFEVKSEFEISWVG 68
            :|.||........|..:.|.:|:.:....|     .:.||  ..:.||| .|.|..|:   ||:
Yeast    56 WQNPNYFKYAWQEYLFIFTCMISQLLNQAG-----TTQTLSIMNILSDS-FGSEGNSK---SWL- 110

  Fly    69 SMLGMGSVTGN-ILIGCLLGRLGSKRCLLLIAIPHSCFWILV----YFAQSVEYLYVGRLLAGIC 128
             |.....|:|: |||...||.:...:.:||:.......|.|:    .::.|..:..:.|...|:
Yeast   111 -MASFPLVSGSFILISGRLGDIYGLKKMLLVGYVLVIIWSLICGITKYSGSDTFFIISRAFQGL- 173

  Fly   129 GGGMYIVHPILLSEIADANIRGTF---------SAMVMLSVNVGILVGYIIGTH----------- 173
              |:..|.|.:|..|.:..:.|||         .||..:...:|.|...:|||.
Yeast   174 --GIAFVLPNVLGIIGNIYVGGTFRKNIVISFVGAMAPIGATLGCLFAGLIGTEDPKQWPWAFYA 236

  Fly   174 ----------LPYYSIPL----------------------MVLILPLW-----------YLISVL 195
                      |..|:||.                      ::|:..:|           |:|.:|
Yeast   237 YSIAAFINFVLSIYAIPSTIPTNIHHFSMDWIGSVLGVIGLILLNFVWNQAPISGWNQAYIIVIL 301

  Fly   196 ----LFIKESPMHLIRIGKYSAAERSFRYYKNIKDSDNIHDQNRAMEEFEIMKIALTKGDALQDA 256
                :|:....::.||..|.....|:.     |||...|          :|| :||..|......
Yeast   302 IISVIFLVVFIIYEIRFAKTPLLPRAV-----IKDRHMI----------QIM-LALFFGWGSFGI 350

  Fly   257 VTFKDFYSR------PALKAYGPALVLLIANQFSGL---FTMVNYMSDIFA-------NSGSTMD 305
            .||..|..:      .||.|.|...:.||....:.|   ||:.|....:|.       |.||
Yeast   351 FTFYYFQFQLNIRQYTALWAGGTYFMFLIWGIIAALLVGFTIKNVSPSVFLFFSMVAFNVGS--- 412

  Fly   306 PDTCTIIIGAVQILGTYVTTLLCDICGRKLLMLVSTGGVAISLTAFGFFTKYAESHNIG-EYSWI 369
                 |:.....:..||..|.|.       .|::.:.|:.:|..|    :....|.|:. ||..:
Yeast   413 -----IMASVTPVHETYFRTQLG-------TMIILSFGMDLSFPA----SSIIFSDNLPMEYQGM 461

  Fly   370 PLLLM------SMDIFLG--------------------------NIGL--VGCFFVSL--VEMFP 398
            ...|:      ||.:.||                          .|||  :.|....|  ||.|.
Yeast   462 AGSLVNTVVNYSMSLCLGMGATVETQVNSDGKHLLKGYRGAQYLGIGLASLACMISGLYMVESFI 526

  Fly   399 VKIRAKAAS 407
            ...||:||:
Yeast   527 KGRRARAAA 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15408	NP_608767.1	2A0115	17..410	CDD:273327	114/518 (22%)
CG15408	NP_608767.1	MFS	60..455	CDD:119392	103/473 (22%)
ATR1	NP_013591.1	MFS_Amf1_MDR_like	73..517	CDD:341029	105/492 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900