DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15408 and VPS73

DIOPT Version :9

Sequence 1:	NP_608767.1	Gene:	CG15408 / 33548	FlyBaseID:	FBgn0031523	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_011411.3	Gene:	VPS73 / 852774	SGDID:	S000003072	Length:	486	Species:	Saccharomyces cerevisiae

Alignment Length:	517	Identity:	116/517 - (22%)
Similarity:	207/517 - (40%)	Gaps:	141/517 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NCLLNRRNRYQLLTTLLINVISISHG-IGIGW-LSPTLRKLQSDSPAGFEVKSE---FEISWVG- 68
            |..:.|:|::::...|...:|..|.| |..|: ||......|..|.:.|::..|   ::.:|:|
Yeast    13 NVSMPRQNKHKITKALCYAIIVASIGSIQFGYHLSELNAPQQVLSCSEFDIPMEGYPYDRTWLGK 77

  Fly    69 ------------------SMLGMGSVTG--------NI-------LIGCLLGRLGSKRCLLLIAI 100
                              |:..:|.:.|        ||       ||.|.|..:||
Yeast    78 RGYKQCIPLNDEQIGIVTSVFCIGGILGSYFATSLANIYGRKFSSLINCTLNIVGS--------- 133

  Fly   101 PHSCFWILVYFAQSVEYLYVGRLLAGICGGGMYIVHPILLSEIADANIRGTFSAMVMLSVNVGIL 165
                  ::::.:.|...|.:||:|.||..|.:.::.|:.:.|:|.:...|...:|..:.:.:|:|
Yeast   134 ------LIIFNSNSYRGLIIGRILVGISCGSLIVIIPLFIKEVAPSGWEGLLGSMTQICIRLGVL 192

  Fly   166 VGYIIGTHLP-----------YYSIPLMVLILPLWYLISVLLFIKESPMHLIRIGKYSAAERSFR 219
            :..  |..||           :.|..:.||...:|:::.      |||..|:..|:.:.|:.|..
Yeast   193 LTQ--GIALPLTDSYRWRWILFGSFLIAVLNFFMWFIVD------ESPKWLLAHGRVTDAKLSLC 249

  Fly   220 YYKNIKDSDNIHDQNRAMEEFEIMKIALTKGDALQDAVT----------FKDFYSRPALKAYGPA 274
            ..:.:...:       |.:|.:..::.:..||.|.:..|          :|....|..:|:....
Yeast   250 KLRGVTFDE-------AAQEIQDWQLQIESGDPLIEPTTTNSISGSNSLWKYLRDRTNVKSRHVI 307

  Fly   275 LVLLIANQFSGLFTMVNYMSDIFANSGSTMDPD---TCTIIIGAVQILGTYVTTLLCDICGRKLL 336
            .|||...||.|:.::|.|.:.|.    |.:.|.   .....|..|.:|.|.:.:||.....||.|
Yeast   308 TVLLFGQQFCGINSIVLYGTKII----SQLYPQHAIRINFFISMVNVLVTILVSLLIHSLPRKPL 368

  Fly   337 MLVSTGGVAISLTAFGFFTKYAESHNIGEYSWIPLLLMSMDIFLG--NIGLVGCFFVSLVEMFPV 399
            ::.||  |.:|:||  |....|.:||     .:.||::...|::|  .:||....|:.:.|:
Yeast   369 LMTST--VLVSVTA--FIMGIAMNHN-----KMNLLIVFSFIYMGVFTMGLNPLPFIIMREV--- 421

  Fly   400 KIRAKAASMAI-----VVCS-IFVFLMLNIFPI-----------------CMKQWGISATMW 438
               :|...|.:     .:|: :..|::...|||                 |    .|||.:|
Yeast   422 ---SKPQDMVLAQRYGTICNWVGTFIIAYTFPIIHDVLSGYVFIIFAIIAC----SISAFIW 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15408	NP_608767.1	2A0115	17..410	CDD:273327	104/457 (23%)
CG15408	NP_608767.1	MFS	60..455	CDD:119392	102/465 (22%)
VPS73	NP_011411.3	MFS_GLUT_Class1_2_like	31..484	CDD:340915	112/499 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342464
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840