DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15408 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_608767.1	Gene:	CG15408 / 33548	FlyBaseID:	FBgn0031523	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_445946.2	Gene:	Slc2a8 / 85256	RGDID:	620611	Length:	478	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	122/470 - (25%)
Similarity:	218/470 - (46%)	Gaps:	49/470 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RYQLLTTLLINVISISHGIGIGWLSPTLRKLQSDSPAGFEVKSEFEISWVGSMLGMGSVTGNILI 82
            |...|.|....:..:|.|..:|:.||.:..|:..:|....: .:...||.|:::.:|:..|.:|.
  Rat    24 RRVFLATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRL-GDTAASWFGAVVTLGAAAGGVLG 87

  Fly    83 GCLLGRLGSKRCLLLIAIPHSCFWILVYFAQSVEYLYVGRLLAGICGGGMYIVHPILLSEIADAN 147
            |.||.|.|.|..|||..:|....:.::..|:.|..|..||||.|:..|...:|.|:.:||||...
  Rat    88 GWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPA 152

  Fly   148 IRGTFSAMVMLSVNVGILVGYIIGTHLPYYSIPLMVLILPLWYLISVLLFIKESPMHLIRIGKYS 212
            :||...:.|.|.|..|||:.|:.|..|.:..:.::..:.|...|: ::.::.|:|..|:...:|.
  Rat   153 VRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLL-LMCYMPETPRFLLTQHQYQ 216

  Fly   213 AAERSFRYYKNIKDSDNIHDQNRAMEEFEIMKIALTKGDALQDAVTFKDFYSRPALKAYGPALV- 276
            .|..:.|:   :..|:...::.....|.:..::|:.:               ||.:  :.|.::
  Rat   217 EAMAALRF---LWGSEEGWEEPPVGAEHQGFQLAMLR---------------RPGV--HKPLIIG 261

  Fly   277 --LLIANQFSGLFTMVNYMSDIFANSGSTMDPDTCTIIIGAVQILGTYVTTLLCDICGRKLLMLV 339
              |::..|.||:..::.|.:.|| ......|....::.:|.:|:|.|.|..|:.|..|||||:.:
  Rat   262 ICLMVFQQLSGVNAIMFYANTIF-EEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRKLLLAL 325

  Fly   340 STGGVAISLTAFGFFTKYAE-----SHNIGEYSWIPLLLMSMDIFLGNIGL-VG--CFFVS---- 392
            |...:..|::|||.:.|..:     |.::|  ..:|:.....|:.||...| ||  |.|::
  Rat   326 SGVIMVFSMSAFGTYFKLTQSGPSNSSHVG--LLVPISAEPADVHLGLAWLAVGSMCLFIAGFAV 388

  Fly   393 ---------LVEMFPVKIRAKAASMAIVVCSIFVFLMLNIFPICMKQWGISATMWSCAGVTALSS 448
                     :.|:||:.|:..|..:.::......||:...|...|:........|..|....||.
  Rat   389 GWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFWLTAAFCILSV 453

  Fly   449 LYFTYFMKETKGKSM 463
            |:...|:.||||:::
  Rat   454 LFTLTFVPETKGRTL 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15408	NP_608767.1	2A0115	17..410	CDD:273327	108/415 (26%)
CG15408	NP_608767.1	MFS	60..455	CDD:119392	107/418 (26%)
Slc2a8	NP_445946.2	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:10671487	12..13
		MFS	27..470	CDD:421695	121/467 (26%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337822
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850