DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15408 and slc2a10

DIOPT Version :9

Sequence 1:	NP_608767.1	Gene:	CG15408 / 33548	FlyBaseID:	FBgn0031523	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_001072926.1	Gene:	slc2a10 / 780388	XenbaseID:	XB-GENE-950490	Length:	555	Species:	Xenopus tropicalis

Alignment Length:	554	Identity:	115/554 - (20%)
Similarity:	205/554 - (37%)	Gaps:	159/554 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TTLLINVISISHGIGIGWLSPTLRKLQSDSPAGFEVKSEFEI------SWVGSMLGMGSVTGNIL 81
            |.:|...:|:..||..|:      :|...|.|...:|:.:::      :.|.::| .|::..:::
Frog     7 TLILAATVSLLGGIVFGY------ELGIISGALLVLKTVYQLTCFEQEALVSAVL-FGALLASLI 64

  Fly    82 IGCLLGRLGSKRCLL----------LIAIPHSCFWILVYFAQSVEYLYVGRLLAGICGGGMYIVH 136
            .|.::.|.|.:..:|          :|.|..|.||          :|.|||:..|.......:..
Frog    65 GGIIIDRWGRRTAILASNLVVLAGSIILIATSTFW----------WLIVGRVTIGFAISISSMAC 119

  Fly   137 PILLSEIADANIRGTFSAMVMLSVNVGILVGYIIGTHL----PYYSIPLMVLILPLWYLISVLLF 197
            .|.:|||...:.||...::....:.||||:.|.:...|    ..:.....:.|:|..:....:||
Frog   120 CIYVSEIVRPHQRGMLVSLYETGITVGILISYAMNYFLSGVNESWKYMFGLAIVPAAFQFISILF 184

  Fly   198 IKESPMHLIRIGKYSAAERSFRYYKNIKDSDNIH-DQNRAMEEFEIMKIALTKGDALQDAVTFKD 261
            :...|..|             .:::...|...|. ::.....||        |.|......||.|
Frog   185 LPSKPHKL-------------NFWEQDTDDGFIELEETGEAGEF--------KPDTYDRQYTFLD 228

  Fly   262 -FYSRPALKA---YGPALVLLIANQFSGLFTMVNYMSDIFANSG--STMDPDTCTIIIGAVQILG 320
             |.|:..::.   .|..|||.  .||:|...::.|.|.||.:.|  |.......::.:|.|::..
Frog   229 LFRSKDNMRTRTLLGLGLVLF--QQFTGQPNVLYYASTIFQSVGFQSNSSAVLASVGLGVVKVAS 291

  Fly   321 TYVTTLLCDICGRKLLMLVSTGGVAISLTAFGF--FTKYAESH----------------NIGE-- 365
            |.:.....|..||::|:|.....:.|::|..|.  ||...:||                |:.:
Frog   292 TLIAICFADKAGRRILLLAGCIVMTIAITGIGIVSFTVKMDSHRDCGSVTGRNMSSGESNVSQLL 356

  Fly   366 ------------------------------------------------------------YSWIP 370
                                                                        .:||.
Frog   357 GIVHAETSTINTLDNSVHQLAMAIRSPSLANSASSNHKDLISQNSTVLPASPELPSNYTILNWIT 421

  Fly   371 LLLMSMDIFLGNIGLVGCFFVSLVEMFPVKIRAKAASMAIVVCSIFVF---LMLNI-FPICMKQW 431
            ||.|...:...:||.....::.|.|::|..||.:    |...|:.|.:   |::.: |...:...
Frog   422 LLSMMAFVSAFSIGFGPMTWIVLSEIYPADIRGR----AFAFCNSFNWAANLLITLTFLDVIASI 482

  Fly   432 GISAT--MWSCAGVTALSSLYFTYFMKETKGKSM 463
            |:|.|  ::...|:.|::.:||  |:.||||:|:
Frog   483 GLSWTFLLYGVVGLLAIAFIYF--FIPETKGQSL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15408	NP_608767.1	2A0115	17..410	CDD:273327	97/493 (20%)
CG15408	NP_608767.1	MFS	60..455	CDD:119392	99/507 (20%)
slc2a10	NP_001072926.1	MFS_GLUT10_Class3	10..517	CDD:340994	114/551 (21%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	250..256		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..555
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53651
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920