DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15408 and SLC2A3

DIOPT Version :9

Sequence 1:	NP_608767.1	Gene:	CG15408 / 33548	FlyBaseID:	FBgn0031523	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_008862.1	Gene:	SLC2A3 / 6515	HGNCID:	11007	Length:	496	Species:	Homo sapiens

Alignment Length:	489	Identity:	122/489 - (24%)
Similarity:	213/489 - (43%)	Gaps:	75/489 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QLLTTLLINVISIS------HGIGIG-----------WLSPTLRKLQSDSPAGFEVKSEFEISWV 67
            |.:|..||..|:::      .|...|           :::.||....:..|:...:.|.:.:|
Human     4 QKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLS-- 66

  Fly    68 GSMLGMGSVTGNILIGCLLGRLGSKRCLL---LIAIPHSCFWILVYFAQSVEYLYVGRLL----A 125
            .::..:|.:.|:..:|..:.|.|.:..:|   |:|:...||..|...|:|||.|.:|||:    .
Human    67 VAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFC 131

  Fly   126 GICGGGMYIVHPILLSEIADANIRGTFSAMVMLSVNVGILVGYIIGTHLPYYSIPLMVL-----I 185
            |:|.|.:    |:.:.||:...:||.|..:..|.:.|||||..|.|......|..|..|     |
Human   132 GLCTGFV----PMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTI 192

  Fly   186 LPLWYLISVLLFIKESPMHLI--RIGKYSAAERSFRYY---------KNIKDSDNIHDQNRAMEE 239
            ||.....:.|.|..|||..|:  |..:.:|.:...|.:         :.:||......|.:.:..
Human   193 LPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTV 257

  Fly   240 FEIMKIALTKGDALQDAVTFKDFYSRPALKAYGPALVLLIANQFSGLFTMVNYMSDIFANSGSTM 304
            .|:.:::               .|.:|.:    .::||.::.|.||:..:..|.:.||.::| ..
Human   258 LELFRVS---------------SYRQPII----ISIVLQLSQQLSGINAVFYYSTGIFKDAG-VQ 302

  Fly   305 DPDTCTIIIGAVQILGTYVTTLLCDICGRKLLMLVSTGGVAISLTAFGFFTKYAESHNIGEYSWI 369
            :|...||..|.|..:.|.|:..|.:..||:.|.::..||:|...|.........:::|...:..|
Human   303 EPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCI 367

  Fly   370 PLLLMSMDIFLGNIGLVGCFFVSLVEMFPVKIRAKAASMAIVVCSIFV--FLMLNIFPICMKQWG 432
            ..:|:.:..|....|.:..|.|:  |:|....|  .|:||:..||.:.  ||:..:||......|
Human   368 GAILVFVAFFEIGPGPIPWFIVA--ELFSQGPR--PAAMAVAGCSNWTSNFLVGLLFPSAAHYLG 428

  Fly   433 ISATMWSCAGVTALSSLYFTYF-MKETKGKSMLD 465
              |.::.......::.|.||:| :.||:|::..|
Human   429 --AYVFIIFTGFLITFLAFTFFKVPETRGRTFED 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15408	NP_608767.1	2A0115	17..410	CDD:273327	105/429 (24%)
CG15408	NP_608767.1	MFS	60..455	CDD:119392	108/420 (26%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	116/475 (24%)
		Important for selectivity against fructose. /evidence=ECO:0000269\|PubMed:26176916	277..279		0/1 (0%)
		Monosaccharide binding. /evidence=ECO:0000269\|PubMed:26176916	280..286		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840