DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15408 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_608767.1	Gene:	CG15408 / 33548	FlyBaseID:	FBgn0031523	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_062361.1	Gene:	Slc2a8 / 56017	MGIID:	1860103	Length:	477	Species:	Mus musculus

Alignment Length:	477	Identity:	124/477 - (25%)
Similarity:	220/477 - (46%)	Gaps:	44/477 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RPNCLLNRRNRYQLLTTLLINVISISHGIGIGWLSPTLRKLQSDSPAGFEVKSEFEISWVGSMLG 72
            ||......|.|...|.:....:..:|.|..:|:.||.:..|:..:|....: .:...||.|:::.
Mouse    14 RPPEARTPRGRRVFLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRL-GDNAASWFGAVVT 77

  Fly    73 MGSVTGNILIGCLLGRLGSKRCLLLIAIPHSCFWILVYFAQSVEYLYVGRLLAGICGGGMYIVHP 137
            :|:..|.||.|.||.|.|.|..|||..:|....:.::..|:.|..|..||||.|:..|...:|.|
Mouse    78 LGAAAGGILGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAP 142

  Fly   138 ILLSEIADANIRGTFSAMVMLSVNVGILVGYIIGTHLPYYSIPLMVLILPLWYLISVLLFIKESP 202
            :.:||||...:||...:.|.|.|..|||:.|:.|..|.:..:.::..:.|...|: ::.::.|:|
Mouse   143 VYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLL-LMCYMPETP 206

  Fly   203 MHLIRIGKYSAAERSFRYYKNIKDSDNIHDQNRAMEEFEIMKIALTKGDALQDAVTFKDFYSRPA 267
            ..|:...:|..|..:.|:   :..|:...::.....|.:..::||.:               ||.
Mouse   207 RFLLTQHQYQEAMAALRF---LWGSEEGWEEPPVGAEHQGFQLALLR---------------RPG 253

  Fly   268 LKAYGPALV---LLIANQFSGLFTMVNYMSDIFANSGSTMDPDTCTIIIGAVQILGTYVTTLLCD 329
            :  |.|.::   |::..|.||:..::.|.:.|| ......|....::.:|.:|:|.|.|..|:.|
Mouse   254 I--YKPLIIGISLMVFQQLSGVNAIMFYANSIF-EEAKFKDSSLASVTVGIIQVLFTAVAALIMD 315

  Fly   330 ICGRKLLMLVSTGGVAISLTAFGFFTKYAES--HNIGEYSWIPLLLMSMDIFLGNIGL-VG--CF 389
            ..||:||:.:|...:..|::|||.:.|..:|  .|......:|:....:|:.:|...| ||  |.
Mouse   316 RAGRRLLLALSGVIMVFSMSAFGTYFKLTQSLPSNSSHVGLVPIAAEPVDVQVGLAWLAVGSMCL 380

  Fly   390 FVS-------------LVEMFPVKIRAKAASMAIVVCSIFVFLMLNIFPICMKQWGISATMWSCA 441
            |::             :.|:||:.::..|..:.::......||:...|...|:........|..|
Mouse   381 FIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWFMAFLVTKEFSSVMEMLRPYGAFWLTA 445

  Fly   442 GVTALSSLYFTYFMKETKGKSM 463
            ...|||.|:....:.||||:::
Mouse   446 AFCALSVLFTLTVVPETKGRTL 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15408	NP_608767.1	2A0115	17..410	CDD:273327	107/413 (26%)
CG15408	NP_608767.1	MFS	60..455	CDD:119392	108/415 (26%)
Slc2a8	NP_062361.1	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:16723738	12..13
		Sugar_tr	29..474	CDD:278511	119/462 (26%)
		MFS	31..459	CDD:119392	115/450 (26%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834253
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840