DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15408 and SLC2A8

DIOPT Version :9

Sequence 1:	NP_608767.1	Gene:	CG15408 / 33548	FlyBaseID:	FBgn0031523	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_055395.2	Gene:	SLC2A8 / 29988	HGNCID:	13812	Length:	477	Species:	Homo sapiens

Alignment Length:	473	Identity:	121/473 - (25%)
Similarity:	212/473 - (44%)	Gaps:	52/473 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RNRYQLLTTLLINVISISHGIGIGWLSPTLRKLQSDSPAGFEVKSEFEISWVGSMLGMGSVTGNI 80
            |.|...|......:..:|.|..:|:.||.:..||..:|....: .:...||.|:::.:|:..|.:
Human    22 RGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRL-DDAAASWFGAVVTLGAAAGGV 85

  Fly    81 LIGCLLGRLGSKRCLLLIAIPHSCFWILVYFAQSVEYLYVGRLLAGICGGGMYIVHPILLSEIAD 145
            |.|.|:.|.|.|..|||.::|....:.::..||.|..|..||||.|:..|...:|.|:.:||||.
Human    86 LGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLVAPVYISEIAY 150

  Fly   146 ANIRGTFSAMVMLSVNVGILVGYIIGTHLPYYSIPLMVLILPLWYLISVLLFIKESPMHLIRIGK 210
            ..:||...:.|.|.|.||||:.|:.|..|.:..:.::..:.|...|: ::.|:.|:|..|:...:
Human   151 PAVRGLLGSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLL-LMCFMPETPRFLLTQHR 214

  Fly   211 YSAAERSFRYYKNIKDSDNIHDQNRAMEEFEI-----MKIALTKGDALQDAVTFKDFYSRPALKA 270
            ...|..:.|:         :....:..|:..|     ..:||     |:....:|.|....:|.|
Human   215 RQEAMAALRF---------LWGSEQGWEDPPIGAEQSFHLAL-----LRQPGIYKPFIIGVSLMA 265

  Fly   271 YGPALVLLIANQFSGLFTMVNYMSDIFANSGSTMDPDTCTIIIGAVQILGTYVTTLLCDICGRKL 335
            :         .|.||:..::.|...|| ......|....::::|.:|:|.|.|..|:.|..||:|
Human   266 F---------QQLSGVNAVMFYAETIF-EEAKFKDSSLASVVVGVIQVLFTAVAALIMDRAGRRL 320

  Fly   336 LMLVSTGGVAISLTAFGFFTKYAESHNIGEYSWI----PLLLMSMDIFLGNIGL-VG--CFFVS- 392
            |:::|...:..|.:|||.:.|..:. ..|..|.:    |:....:|..:|...| ||  |.|::
Human   321 LLVLSGVVMVFSTSAFGAYFKLTQG-GPGNSSHVAISAPVSAQPVDASVGLAWLAVGSMCLFIAG 384

  Fly   393 ------------LVEMFPVKIRAKAASMAIVVCSIFVFLMLNIFPICMKQWGISATMWSCAGVTA 445
                        :.|:||:.::..|..:.::...:..||:...|...|:........|..:....
Human   385 FAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLMAFLVTKEFSSLMEVLRPYGAFWLASAFCI 449

  Fly   446 LSSLYFTYFMKETKGKSM 463
            .|.|:..:.:.|||||::
Human   450 FSVLFTLFCVPETKGKTL 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15408	NP_608767.1	2A0115	17..410	CDD:273327	108/417 (26%)
CG15408	NP_608767.1	MFS	60..455	CDD:119392	105/419 (25%)
SLC2A8	NP_055395.2	Dileucine internalization motif. /evidence=ECO:0000250\|UniProtKB:Q9JJZ1	12..13
		xylE	36..472	CDD:182225	118/459 (26%)
		MFS	38..459	CDD:119392	113/447 (25%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	267..273		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144063
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850