DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15408 and Slc2a4

DIOPT Version :9

Sequence 1:	NP_608767.1	Gene:	CG15408 / 33548	FlyBaseID:	FBgn0031523	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_036883.1	Gene:	Slc2a4 / 25139	RGDID:	2711	Length:	509	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	111/512 - (21%)
Similarity:	195/512 - (38%)	Gaps:	132/512 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 TLLINVI-----SISHGIGIGWLSPTLRKLQSDSPAGFEVKSEFEISWVG--------------- 68
            ||::.|.     |:..|..||.::...:          .::..:..:|:|
  Rat    23 TLVLAVFSAVLGSLQFGYNIGVINAPQK----------VIEQSYNATWLGRQGPGGPDSIPQGTL 77

  Fly    69 --------SMLGMGSVTGNILIGCLLGRLGSKRCLL---LIAIPHSCFWILVYFAQSVEYLYVGR 122
                    ::..:|.:..:.|||.:...||.||.:|   ::|:.......|...|.|.|.|.:||
  Rat    78 TTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGR 142

  Fly   123 LLAGICGGGMYIVHPILLSEIADANIRGTFSAMVMLSVNVGILVGYIIGTH-----LPYYSIPLM 182
            .|.|...|....:.|:.:.|||..::||....:..|::.:||||..::|..     ...:.:.|.
  Rat   143 FLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPLLLA 207

  Fly   183 VLILPLWYLISVLLFIKESPMHLIRIGKYSA-AERSFRY---YKNIKDS-DNIHDQNRAMEEFEI 242
            :.:||....:.:|.|..|||.:|..|..... |.:|.:.   :.::.|: ..:.|:.|.:|....
  Rat   208 ITVLPALLQLLLLPFCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKRKLERERP 272

  Fly   243 MKIALTKGDALQDAVTFKDFYSRPALKAYGPALVLLIANQFSGLFTMVNYMSDIFANSGSTMDPD 307
            :.:....|             ||...:....|:||.::.|.||:..:..|.:.||..:| ...|.
  Rat   273 LSLLQLLG-------------SRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFELAG-VEQPA 323

  Fly   308 TCTIIIGAVQILGTYVTTLLCDICGRKLLMLVSTGGV---AISLTAFGFFTKYAESHNIGEYSWI 369
            ..||..|.|..:.|.|:.||.:..||:.|.|:...|:   ||.:|                   :
  Rat   324 YATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMT-------------------V 369

  Fly   370 PLLLMSMDIFLGNIGLVGCF-FVSLVEMFPVKIRAKAASMAIVVCSIFVFLMLNIF-----PICM 428
            .|||:.....:..:.:|..| ||:..|:.|..|.              .|::..:|     |..|
  Rat   370 ALLLLERVPSMSYVSIVAIFGFVAFFEIGPGPIP--------------WFIVAELFSQGPRPAAM 420

  Fly   429 KQWGISATMWSCAGVTALSSLY----------------------FTYF-MKETKGKS 462
            ...|.|  .|:|..:..:...|                      ||:. :.||:|::
  Rat   421 AVAGFS--NWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRT 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15408	NP_608767.1	2A0115	17..410	CDD:273327	97/430 (23%)
CG15408	NP_608767.1	MFS	60..455	CDD:119392	101/462 (22%)
Slc2a4	NP_036883.1	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13
		Sugar_tr	27..483	CDD:278511	109/508 (21%)
		MFS	78..447	CDD:119392	97/417 (23%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		3/5 (60%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337879
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840