DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15408 and SLC2A6

DIOPT Version :9

Sequence 1:	NP_608767.1	Gene:	CG15408 / 33548	FlyBaseID:	FBgn0031523	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_060055.2	Gene:	SLC2A6 / 11182	HGNCID:	11011	Length:	507	Species:	Homo sapiens

Alignment Length:	488	Identity:	115/488 - (23%)
Similarity:	212/488 - (43%)	Gaps:	70/488 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RNRYQLLTTLLINVISISHGIGIGWLSPTLRKLQ-SDSPAGFEVKSEFEISWVGSMLGMGSVTGN 79
            :|:...|.|....:.:.|.|..:.:.||.:..|: |..|.....||  :.||.||:..:|:..|.
Human    34 QNKRVFLATFAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKS--QASWFGSVFTLGAAAGG 96

  Fly    80 ILIGCLLGRLGSKRCLLLIAIPHSCFWILVYFAQSVEYLYVGRLLAGICGGGMYIVHPILLSEIA 144
            :....|...||.|..::..|:|.:..:.|:..|..:..|.:||.|.|..||......|:.:||||
Human    97 LSAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSEIA 161

  Fly   145 DANIRGTFSAMVMLSVNVGILVGYIIGTHLPYY------SIPLMVLILPLWYLISVLLFIKESPM 203
            ...:||...|...|....|.|..|.:|..||:.      ..|::::||       :|.|:..||.
Human   162 PPGVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEAPVLIMIL-------LLSFMPNSPR 219

  Fly   204 HLIRIGKYSAAERSFRYYKNIKDSD-NIHDQNRAMEEFEIMKIALTKGDALQDAVTFKDFYSRPA 267
            .|:..|:...|.|:..:   ::.:| ::|      .|||          .:||.|..:.  ||.:
Human   220 FLLSRGRDEEALRALAW---LRGTDVDVH------WEFE----------QIQDNVRRQS--SRVS 263

  Fly   268 -LKAYGP--------ALVLLIANQFSGLFTMVNYMSDIFANSGSTMDPDTCTIIIGAVQILGTYV 323
             .:|..|        ||::.:..|.:|:..::.|:..||.::...:.|.....|:|||::|...:
Human   264 WAEARAPHVCRPITVALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLI 328

  Fly   324 TTLLCDICGRKLLMLVSTGGVAISLTAFGFFTKYA------------ESHNIGE----------- 365
            ..|..|:.|||:|:.||...:..:....|.:..:.            ||.:.|:
Human   329 AALTMDLAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLAAPAGY 393

  Fly   366 YSWIPLLLMSMDIFLGNIGLVGCFFVSLVEMFPVKIRAKAASMAIVVCSIFVFLMLNIFPICMKQ 430
            .:.:|||...:.|....:|.....::.:.|:.|::.|..|:.:.::...:..|::...|...:..
Human   394 LTLVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVST 458

  Fly   431 WGISATMWSCAGVTALSSLYFTYFMKETKGKSM 463
            :|:....:..|.:..:|.::....:.||||:|:
Human   459 FGLQVPFFFFAAICLVSLVFTGCCVPETKGRSL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15408	NP_608767.1	2A0115	17..410	CDD:273327	105/432 (24%)
CG15408	NP_608767.1	MFS	60..455	CDD:119392	99/433 (23%)
SLC2A6	NP_060055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS_GLUT6_Class3	39..493	CDD:340992	114/483 (24%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	286..292		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144141
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53651
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860