DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3285 and VPS73

DIOPT Version :9

Sequence 1:	NP_001285583.1	Gene:	CG3285 / 33547	FlyBaseID:	FBgn0031522	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_011411.3	Gene:	VPS73 / 852774	SGDID:	S000003072	Length:	486	Species:	Saccharomyces cerevisiae

Alignment Length:	497	Identity:	112/497 - (22%)
Similarity:	202/497 - (40%)	Gaps:	95/497 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRLASVFANPNCLLGRRIRHQFLVTLLLNIATFSHG-LGVGW-----------MSPVMRDLQTDE 57
            |..||:.:|.:  :.|:.:|:....|...|...|.| :..|:           :|....|:..:.
Yeast     5 LSSASLLSNVS--MPRQNKHKITKALCYAIIVASIGSIQFGYHLSELNAPQQVLSCSEFDIPMEG 67

  Fly    58 SPLD------------FPVLVSQVSWIGSLVGIGSVMGNLIAGLLMDRIGRKMVLFFIAIPYTTF 110
            .|.|            .|:...|:..:.|:..||.::|:..|..|.:..|||.............
Yeast    68 YPYDRTWLGKRGYKQCIPLNDEQIGIVTSVFCIGGILGSYFATSLANIYGRKFSSLINCTLNIVG 132

  Fly   111 WCLIYFVQSVEFLYIGRLMAGITGGACYVVLPTFISEIADTNVRGRLGSIILLSVNTGVLAGYIV 175
            ..:|:...|...|.|||::.||:.|:..|::|.||.|:|.:...|.|||:..:.:..|||....:
Yeast   133 SLIIFNSNSYRGLIIGRILVGISCGSLIVIIPLFIKEVAPSGWEGLLGSMTQICIRLGVLLTQGI 197

  Fly   176 ------STRVDYFTSPPFIIGLPVCYFICNFLIPETPHHLVRKGKFEAAKRSFMFYKNIRKNDIK 234
                  |.|..:.....|:|.  |..|...|::.|:|..|:..|:...||.|....:.:..::
Yeast   198 ALPLTDSYRWRWILFGSFLIA--VLNFFMWFIVDESPKWLLAHGRVTDAKLSLCKLRGVTFDE-- 258

  Fly   235 AEDEFEEMKYL------LIKEQTEKAKS-----FDY-RDFITRPAFKAYASAAVLLISNQFSASF 287
            |..|.::.:..      ||:..|..:.|     :.| ||   |...|:.....|||...||....
Yeast   259 AAQEIQDWQLQIESGDPLIEPTTTNSISGSNSLWKYLRD---RTNVKSRHVITVLLFGQQFCGIN 320

  Fly   288 CVTTY----LADVFAASHTTLN--LGMCTIIIGVLQIVGNYVTTLLCDKYGRRILMLTSTLGASV 346
            .:..|    ::.::......:|  :.|..:::.:|       .:||.....|:.|::|||:..||
Yeast   321 SIVLYGTKIISQLYPQHAIRINFFISMVNVLVTIL-------VSLLIHSLPRKPLLMTSTVLVSV 378

  Fly   347 CLTAFGTFTFFAEAADLSSVDWLPLVILSCFVFL--CNIGLVGCLFVVLVELFPAKIRSVS---- 405
              |||    ....|.:.:.::   |:|:..|:::  ..:||....|:::.|:...:...::
Yeast   379 --TAF----IMGIAMNHNKMN---LLIVFSFIYMGVFTMGLNPLPFIIMREVSKPQDMVLAQRYG 434

  Fly   406 -----VSTFVV---------ILSSTVFLTLKIF--PICMAVW 431
                 |.||::         :||..||:...|.  .|...:|
Yeast   435 TICNWVGTFIIAYTFPIIHDVLSGYVFIIFAIIACSISAFIW 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3285	NP_001285583.1	MFS	29..443	CDD:119392	106/473 (22%)
CG3285	NP_001285583.1	MFS_1	32..419	CDD:284993	101/454 (22%)
VPS73	NP_011411.3	MFS_GLUT_Class1_2_like	31..484	CDD:340915	105/469 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342454
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840