DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3285 and HXT3

DIOPT Version :9

Sequence 1:	NP_001285583.1	Gene:	CG3285 / 33547	FlyBaseID:	FBgn0031522	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_010632.1	Gene:	HXT3 / 851946	SGDID:	S000002753	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	534	Identity:	127/534 - (23%)
Similarity:	208/534 - (38%)	Gaps:	129/534 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FKLRLASVFANPNCLLGRRIRHQFLVTLLLNIATFSHGLGVGWMSPVMRDL--QTD------ESP 59
            |:.....|..|||...|..:    .|::...:..|. |...||.:..:...  |||      ...
Yeast    41 FQAEADQVLTNPNTGKGAYV----TVSICCVMVAFG-GFVFGWDTGTISGFVAQTDFLRRFGMKH 100

  Fly    60 LDFPVLVSQV--SWIGSLVGIGSVMGNLIAGLLMDRIGRKMVLFFIAIPYTTFWCLIYFVQSVEF 122
            .|....:|:|  ..|.|:..||..:|.:|...|.|..||||.|..:.:.|..  .:|..:.|:..
Yeast   101 KDGSYYLSKVRTGLIVSIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYII--GIIIQIASINK 163

  Fly   123 LY---IGRLMAGITGGACYVVLPTFISEIADTNVRGRLGSIILLSVNTGVLAGYIVS--TRVDYF 182
            .|   |||:::|:..|...|:.|..|||:|...:||.|.|...|.:..|:..||..:  |: :|.
Yeast   164 WYQYFIGRIISGLGVGGIAVLSPMLISEVAPKEMRGTLVSCYQLMITLGIFLGYCTNFGTK-NYS 227

  Fly   183 TSPPFIIGLPVCYFICNFLI------PETPHHLVRKGKFEAAKRSFMFYKNIRKNDIKAEDEFEE 241
            .|..:.:.|.:|:....|:|      ||:|.:||..|:.:.|:.|..     :.|.:..:..|.:
Yeast   228 NSVQWRVPLGLCFAWALFMIGGMTFVPESPRYLVEAGQIDEARASLS-----KVNKVAPDHPFIQ 287

  Fly   242 MKYLLIKEQTEKAK---SFDYRDFIT-RPA-FKAYASAAVLLISNQFSASFCVTTYLADVFAASH 301
            .:..:|:...|:|:   |..:.:..| :|| ||......::....|.:.......|...||.|
Yeast   288 QELEVIEASVEEARAAGSASWGELFTGKPAMFKRTMMGIMIQSLQQLTGDNYFFYYGTTVFNA-- 350

  Fly   302 TTLNLGM-----CTIIIGVLQIVGNYVTTLLCDKYGRRILMLTSTLG--------ASV------- 346
                :||     .:|:.||:.......:....|::|||..:|...:|        |||
Yeast   351 ----VGMSDSFETSIVFGVVNFFSTCCSLYTVDRFGRRNCLLYGAIGMVCCYVVYASVGVTRLWP 411

  Fly   347 -------------CLTAFGTFTFFAEAADLSSVDWLPLVILSCFVFLCNIGLVGCLFVVLVELFP 398
                         |:..|..|..|..|     ..|.|:.                 :||:.|.||
Yeast   412 NGEGNGSSKGAGNCMIVFACFYIFCFA-----TTWAPIA-----------------YVVISETFP 454

  Fly   399 AKIRSVSVSTFVVILSSTVFLTLKIFPICMAVWGTSV---TMWSCSGITF-----------FSFL 449
            .:::|.::|    |.::..:|           ||..:   |.:....|.|           |::.
Yeast   455 LRVKSKAMS----IATAANWL-----------WGFLIGFFTPFITGAINFYYGYVFMGCMVFAYF 504

  Fly   450 YFCFFLEETNGKSL 463
            |..||:.||.|.:|
Yeast   505 YVFFFVPETKGLTL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3285	NP_001285583.1	MFS	29..443	CDD:119392	110/475 (23%)
CG3285	NP_001285583.1	MFS_1	32..419	CDD:284993	106/445 (24%)
HXT3	NP_010632.1	Sugar_tr	65..525	CDD:395036	120/506 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342512
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.740