DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3285 and Slc2a4

DIOPT Version :9

Sequence 1:	NP_001285583.1	Gene:	CG3285 / 33547	FlyBaseID:	FBgn0031522	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_036883.1	Gene:	Slc2a4 / 25139	RGDID:	2711	Length:	509	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	109/507 - (21%)
Similarity:	190/507 - (37%)	Gaps:	123/507 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VTLLLNIATFSHGLG-------VGWMSPVMRDLQTDESPLDFPVLVSQVSWIG------------ 73
            ||..|.:|.||..||       :|.::...:.::...:          .:|:|
  Rat    20 VTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYN----------ATWLGRQGPGGPDSIPQ 74

  Fly    74 -----------SLVGIGSVMGNLIAGLLMDRIGRKMVLF---FIAIPYTTFWCLIYFVQSVEFLY 124
                       ::..:|.::.:.:.|::...:|||..:.   .:|:.......|.....|.|.|.
  Rat    75 GTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILI 139

  Fly   125 IGRLMAGITGGACYVVLPTFISEIADTNVRGRLGSIILLSVNTGVLAGYI--VSTRVDYFTSPPF 187
            :||.:.|...|....::|.::.|||.|::||.||::..|::..|:|...:  :.:.:...|..|.
  Rat   140 LGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPL 204

  Fly   188 IIGLPVCYFICNFLI----PETPHHLVRKGKFEAAKRSFMFYKNIRK-------NDIKAE--DEF 239
            ::.:.|...:...|:    ||:|.:|......|...|     |::::       :|..||  ||
  Rat   205 LLAITVLPALLQLLLLPFCPESPRYLYIIRNLEGPAR-----KSLKRLTGWADVSDALAELKDE- 263

  Fly   240 EEMKYLLIKEQTEKAKSFDYRDFI-TRPAFKAYASAAVLLISNQFSASFCVTTYLADVFAASHTT 303
                    |.:.|:.:.......: :|...:....|.||.:|.|.|....|..|...:|..:...
  Rat   264 --------KRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFELAGVE 320

  Fly   304 LNLGMCTIIIGVLQIVGNYVTTLLCDKYGRRILMLTSTLGASVCLTAFGTFTFFAEAADLSSVDW 368
             .....||..||:..|...|:.||.::.|||.|.|....|...|...........|.  :.|:.:
  Rat   321 -QPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLER--VPSMSY 382

  Fly   369 LPLVILSCFVFLCNIGLVGCLFVVLVELFPAKIRSVSVSTFVVILSSTVFLTLKIFPICMAVWGT 433
            :.:|.:..||....||.....:.::.|||....|                      |..|||.|.
  Rat   383 VSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPR----------------------PAAMAVAGF 425

  Fly   434 SVTMWSCS---GITF---------FSFLYFC-----FFL------EETNGKS 462
            |  .|:|:   |:.|         :.||.|.     ||:      .||.|::
  Rat   426 S--NWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRT 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3285	NP_001285583.1	MFS	29..443	CDD:119392	98/465 (21%)
CG3285	NP_001285583.1	MFS_1	32..419	CDD:284993	89/435 (20%)
Slc2a4	NP_036883.1	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13
		Sugar_tr	27..483	CDD:278511	106/500 (21%)
		MFS	78..447	CDD:119392	90/409 (22%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		2/5 (40%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337874
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840