DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3285 and Slc2a4

DIOPT Version :9

Sequence 1:	NP_001285583.1	Gene:	CG3285 / 33547	FlyBaseID:	FBgn0031522	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_033230.2	Gene:	Slc2a4 / 20528	MGIID:	95758	Length:	509	Species:	Mus musculus

Alignment Length:	515	Identity:	112/515 - (21%)
Similarity:	194/515 - (37%)	Gaps:	139/515 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VTLLLNIATFSHGLG-------VGWMSPVMRDLQTDESPLDFPVLVSQVSWIG------------ 73
            ||..|.:|.||..||       :|.::...:.::...:          .:|:|
Mouse    20 VTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYN----------ATWLGRQGPGGPDSIPQ 74

  Fly    74 -----------SLVGIGSVMGNLIAGLLMDRIGRKMVLF---FIAIPYTTFWCLIYFVQSVEFLY 124
                       ::..:|.::.:.:.|::...:|||..:.   .:|:.......|.....|.|.|.
Mouse    75 GTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILI 139

  Fly   125 IGRLMAGITGGACYVVLPTFISEIADTNVRGRLGSIILLSVNTGVLAGYI--VSTRVDYFTSPPF 187
            :||.:.|...|....::|.::.|||.|::||.||::..|::..|:|...:  :.:.:...|..|.
Mouse   140 LGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPL 204

  Fly   188 IIGLPVCYFICNFLI----PETPHHLVRKGKFEAAKRSFMFYKNIRK-------NDIKAE--DEF 239
            ::.|.|...:...::    ||:|.:|......|...|     |::::       :|..||  ||
Mouse   205 LLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPAR-----KSLKRLTGWADVSDALAELKDE- 263

  Fly   240 EEMKYLLIKEQTEKAKSFDYRDFI-TRPAFKAYASAAVLLISNQFSASFCVTTYLADVFAASHTT 303
                    |.:.|:.:.......: :|...:....|.||.:|.|.|....|..|...:|.::
Mouse   264 --------KRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESA--- 317

  Fly   304 LNLGM---CTIIIGVLQIVGNYVTTLLCDKYGRRILMLTSTLGASVCLTAFGTFTFFAEAADLSS 365
             .:|.   .||..||:..|...|:.||.::.|||.|.|....|...|             |.|.:
Mouse   318 -GVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGC-------------AILMT 368

  Fly   366 VDWLPLVILSCFVFLCNIGLVGCLFVVLVELFPAKIRSVSVSTFVVILSSTVFLTLKIF-----P 425
            |..|.|..:....::..:.:.|  ||...|:.|..|              ..|:..::|     |
Mouse   369 VALLLLERVPAMSYVSIVAIFG--FVAFFEIGPGPI--------------PWFIVAELFSQGPRP 417

  Fly   426 ICMAVWGTSVTMWSCSGITFFSFLY--------------------FCF-FLE--ETNGKS 462
            ..|||.|.|  .|:|:.|....|.|                    |.| ||:  ||.|::
Mouse   418 AAMAVAGFS--NWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGRT 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3285	NP_001285583.1	MFS	29..443	CDD:119392	101/470 (21%)
CG3285	NP_001285583.1	MFS_1	32..419	CDD:284993	90/438 (21%)
Slc2a4	NP_033230.2	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13
		Sugar_tr	27..483	CDD:278511	109/508 (21%)
		MFS	78..447	CDD:119392	94/417 (23%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		2/5 (40%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834305
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840