DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8837 and HXT4

DIOPT Version :9

Sequence 1:	NP_001285582.1	Gene:	CG8837 / 33545	FlyBaseID:	FBgn0031520	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_011960.2	Gene:	HXT4 / 856492	SGDID:	S000001134	Length:	576	Species:	Saccharomyces cerevisiae

Alignment Length:	480	Identity:	106/480 - (22%)
Similarity:	183/480 - (38%)	Gaps:	61/480 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 CLPKRVGGPAI-QSVATALGNILCFNFGLMFGITPAHMTLYESEERTPLNQATDPAGTAWLTGYL 65
            ||....||... ....|..|.:...:|...||:.....|.|.|:.||.|           :....
Yeast    75 CLMVAFGGFVFGWDTGTISGFVAQTDFIRRFGMKHHDGTYYLSKVRTGL-----------IVSIF 128

  Fly    66 FLSAALGALVSGFLALKIGPKSVLLCSGLLQISG----WACIHFGYDIVHIYASRLFAGVASGAA 126
            .:..|:|.::...|....|.|..|:...::.|.|    .|.|:..|   ..:..|:.:|:..|..
Yeast   129 NIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWY---QYFIGRIISGLGVGGI 190

  Fly   127 FVVLPIFINEIAESREKAARLTFTIELWRTLGILIGFVLGFYVPYAFVNIV--------GCAVSF 183
            .|:.|:.|:|::....:.. |....:|..||||.:|:... |....:.|.|        |.|.:.
Yeast   191 AVLSPMLISEVSPKHIRGT-LVSCYQLMITLGIFLGYCTN-YGTKTYTNSVQWRVPLGLGFAWAL 253

  Fly   184 VFTMTFPFVQESPHYYLRKNNMASLEKSLRWYRGIRDIDDREKPEYLSELNEFHAELRSRDKNVG 248
            .......||.|||.|.:....:...::|:.....: ..||   |..::|:....|.:.: :|..|
Yeast   254 FMIGGMTFVPESPRYLVEVGKIEEAKRSIALSNKV-SADD---PAVMAEVEVVQATVEA-EKLAG 313

  Fly   249 STPMSHGY-----IIRLTFVSFLLTVCAKLSGVFVELNYAADFLGRTGY--STETNYVVLASAQC 306
            :......:     :.:...:..::....:|:|......|........|.  |.||: :||.....
Yeast   314 NASWGEIFSTKTKVFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTAVGLEDSFETS-IVLGIVNF 377

  Fly   307 AGALLARLVGPRLPRKLLLCLSSLFAAAAVIA-LALFKAYG--HLWLLG--NWADR---YLPIIL 363
            |...:...:..|..|:  .||  |:.||::.| :.:|.:.|  .||..|  |.:.:   ...|:.
Yeast   378 ASTFVGIFLVERYGRR--RCL--LWGAASMTACMVVFASVGVTRLWPNGKKNGSSKGAGNCMIVF 438

  Fly   364 LAIQLALVSFGLYPLAAVVSSEVLPTKLHDLLYSLASAVSWL--LLFGMIEAFNAVKATIAPGLL 426
            ....|...:....|:..||:||..|.::.....::|.|.:|:  .|.|....|  :...|.   .
Yeast   439 TCFYLFCFATTWAPIPFVVNSETFPLRVKSKCMAIAQACNWIWGFLIGFFTPF--ISGAID---F 498

  Fly   427 LYLWVFAGASIFVGLISLPLLPETR 451
            .|.:||.|..:|........:|||:
Yeast   499 YYGYVFMGCLVFSYFYVFFFVPETK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	30/149 (20%)
CG8837	NP_001285582.1	Sugar_tr	58..453	CDD:278511	91/423 (22%)
HXT4	NP_011960.2	Sugar_tr	74..534	CDD:395036	106/480 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342359
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740