DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8837 and ATR2

DIOPT Version :9

Sequence 1:	NP_001285582.1	Gene:	CG8837 / 33545	FlyBaseID:	FBgn0031520	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_014006.1	Gene:	ATR2 / 855322	SGDID:	S000004892	Length:	540	Species:	Saccharomyces cerevisiae

Alignment Length:	576	Identity:	120/576 - (20%)
Similarity:	176/576 - (30%)	Gaps:	228/576 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 CLPKRVGGPAIQSVATALGNILCFNFGLMFGITPAHMTLYESEERTPLNQATDPAGTAWLTGYLF 66
            |:..::...|.|:.|..:.|:|..:|              .||..   ||       |||.....
Yeast    76 CMLAQLLNQAGQTHALCIMNVLSKSF--------------NSEAN---NQ-------AWLMASFP 116

  Fly    67 LSAALGALVSGFLALKIGPKSVLLCSGLLQISGWACI----HFGYDIVHIYASRLFAGVASGAAF 127
            |:|....|:||.|....|.|.:|:. |.:.:..|:.|    .:.........||.|.||  |.||
Yeast   117 LAAGSFILISGRLGDIYGLKKMLIV-GYVIVIVWSIISGLSKYSNSDAFFITSRAFQGV--GIAF 178

  Fly   128 VVLPIFINEIAE-----SREKAARLTFTIELWRTLGILIGFVLGF----------YVPYAF---- 173
             :||..:..:..     |..|...::|......|.|:..|...|.          :|.|||
Yeast   179 -ILPNIMGLVGHVYKVGSFRKNIVISFIGACAPTGGMFGGLFGGLIVTEDPNQWPWVFYAFGIAT 242

  Fly   174 ----------------VNI-------VGCAVSFVFTMTFPFVQESPHYYLRKNNMASLEKSLRWY 215
                            .||       .|.|::.:..:.|.||.          |.|.:   :.|
Yeast   243 FLSLLMAWYSIPNNVPTNIHGLSMDWTGSALAIIGLILFNFVW----------NQAPI---VGW- 293

  Fly   216 RGIRDIDDREKPEYLSELNEFHAELRSRDKNVGSTPMSHGYIIRLTFVSFLLTVCAKLSGVFV-E 279
                     :||                            |||.|..:|.:..|     ..|| |
Yeast   294 ---------DKP----------------------------YIIVLLIISVIFLV-----AFFVYE 316

  Fly   280 LNYA--------------------ADFLGRTGYSTETNYVVLASAQCA----------------- 307
            ..||                    |.|||...:...|.|.|.......
Yeast   317 SKYAEVPLLPRAMTKNRHMIMILLAVFLGWGSFGIWTFYYVSFQLNLRHYSPVWTGGTYFVFVIF 381

  Fly   308 GALLARLVG---PRLPRKLLLCLSSLFAAAAVIALALFKAYGHLWLLGNWADRYLPIILLAIQLA 369
            |::.|..|.   .||...||||.|.:...|..|..::.......|.|.           .|:| |
Yeast   382 GSMAAFFVAFSIKRLGPALLLCFSLMAFDAGSIMFSVLPVEQSYWKLN-----------FAMQ-A 434

  Fly   370 LVSFGL---YPLAAVVSSEVLPTKLHDLLYSLASAV---SWLLLFGM---------------IEA 413
            ::.||:   :|.::::.|:.||.:...:..||.:.|   |..|..||               ::.
Yeast   435 ILCFGMDLSFPASSIILSDGLPMQYQGMAGSLVNTVINYSASLCLGMGGTVEHQINKSGNDLLKG 499

  Fly   414 FNAVKATIAPGLLLYLWVFAGASIFVGLISLP-------LLPETRNRRPSAVQREL 462
            :.|.             |:.|    |||.||.       :|....||...:..|.|
Yeast   500 YRAA-------------VYLG----VGLASLGVVISVTYMLENLWNRHRKSEDRSL 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	41/183 (22%)
CG8837	NP_001285582.1	Sugar_tr	58..453	CDD:278511	105/509 (21%)
ATR2	NP_014006.1	MFS_Amf1_MDR_like	74..519	CDD:341029	115/555 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900