DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8837 and ITR2

DIOPT Version :9

Sequence 1:	NP_001285582.1	Gene:	CG8837 / 33545	FlyBaseID:	FBgn0031520	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_014538.2	Gene:	ITR2 / 854050	SGDID:	S000005463	Length:	609	Species:	Saccharomyces cerevisiae

Alignment Length:	500	Identity:	117/500 - (23%)
Similarity:	185/500 - (37%)	Gaps:	94/500 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GLMFGITPAHMTLYESEERTPLNQATDPAGTAWLTGYLFLSA-ALGALV----SGFLALKIGPKS 87
            |.|||    :.|.|.|.....:|:..|.....:....|..:| :||||:    :|..|...|.:.
Yeast   120 GFMFG----YDTGYISSALISINRDLDNKVLTYGEKELITAATSLGALITSVGAGTAADVFGRRP 180

  Fly    88 VLLCSGLLQISGWACIHFGYDIVHIYASRLFAGVASGAAFVVLPIFINEIAESREKAARLTFTIE 152
            .|:.|.|:.:.|.......:....:.|.||..|...|...::.|:||:|||....: .|||....
Yeast   181 CLMFSNLMFLIGAILQITAHKFWQMAAGRLIMGFGVGIGSLISPLFISEIAPKMIR-GRLTVINS 244

  Fly   153 LWRTLGILIGFVLGF---YVPYAFVNIVGCA-----VSFVFTMTFPFVQESPHYYLRKNNMASLE 209
            ||.|.|.||.:..|.   :|...:..:||.:     :.|.|   |.|:.::|.||:.|.::...:
Yeast   245 LWLTGGQLIAYGCGAGLNHVKNGWRILVGLSLIPTVLQFSF---FCFLPDTPRYYVMKGDLKRAK 306

  Fly   210 KSL-RWYRGIRDIDDREKPEYLSELNEFHAELRSRDKNVGSTPMSHGYIIRLTFVSFLLTVCAKL 273
            ..| |.|....|....:|.|.||.||:         ...|..|::..:    ..|..|.||.:..
Yeast   307 MVLKRSYVNTEDEIIDQKVEELSSLNQ---------SIPGKNPITKFW----NMVKELHTVPSNF 358

  Fly   274 SGVFVELNYAA--DFLG-------------RTGYSTE---------TNYV-VLASAQCAGALLAR 313
            ..:.:.....|  .|.|             ..|:...         ||:| .|.:..|...:..|
Yeast   359 RALIIGCGLQAIQQFTGWNSLMYFSGTIFETVGFKNSSAVSIIVSGTNFVFTLIAFFCIDKIGRR 423

  Fly   314 ---LVG-PRLPRKLLLCLSSLF-------AAAAVIALALFKAYGHLWLLGNWADRYLPIILLAIQ 367
               |:| |.:...|::|..:..       .|.||:|...|.::|              |:::...
Yeast   424 YILLIGLPGMTVALVICAIAFHFLGIKFNGADAVVASDGFSSWG--------------IVIIVFI 474

  Fly   368 LALVSFGLYPLAAV--VSSEVLPTKLHDLLYSLASAVSWLLLFGMIEAFNAVKATIAP-GLLLYL 429
            :...:|....:..|  ..||:.|..:..:..|.|:|.:|.....:...|..:...|.| |...:
Yeast   475 IVYAAFYALGIGTVPWQQSELFPQNVRGVGTSYATATNWAGSLVIASTFLTMLQNITPTGTFSF- 538

  Fly   430 WVFAGASIFVGLISLPLLPETRNRRPSAVQRELGYVDDGGVAKGS 474
              |||.:....:......||........||..|   .||...|.|
Yeast   539 --FAGVACLSTIFCYFCYPELSGLELEEVQTIL---KDGFNIKAS 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	41/150 (27%)
CG8837	NP_001285582.1	Sugar_tr	58..453	CDD:278511	101/447 (23%)
ITR2	NP_014538.2	MFS_HMIT_like	115..556	CDD:340918	108/473 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342331
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740