DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8837 and ENB1

DIOPT Version :9

Sequence 1:	NP_001285582.1	Gene:	CG8837 / 33545	FlyBaseID:	FBgn0031520	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_014484.1	Gene:	ENB1 / 854007	SGDID:	S000005518	Length:	606	Species:	Saccharomyces cerevisiae

Alignment Length:	526	Identity:	105/526 - (19%)
Similarity:	180/526 - (34%)	Gaps:	176/526 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VGGPAIQSVATALGNILCFNFG--LMFGITPAHMTLYESEERTPLNQATDPAG--TAWLTGYLFL 67
            :||...||:.|...|    :||  ...|......::..|....|..:.:|..|  ..|:  :..:
Yeast    79 LGGQISQSIQTYAAN----SFGKHSQVGSINTVKSIVASVVAVPYARISDRFGRIECWI--FALV 137

  Fly    68 SAALGALVSGFLALKIGPKSVLLCSGLLQISGWACIHFGYDIVHIYASRLFAGVASGAA------ 126
            ...:|.::|.         :....|||  .:|.....|||....:.|:.| .|..||..
Yeast   138 LYTIGEIISA---------ATPTFSGL--FAGIVIQQFGYSGFRLLATAL-TGDLSGLRDRTFAM 190

  Fly   127 -FVVLPIFINEIAESREKAARLTFTIELWRTLGILIGFVLGFYVPYAFVNIVGCAVSFVFTMTFP 190
             ..::|:.||                 .| ..|.::..|.|...||.:....|     :|.:..|
Yeast   191 NIFLIPVIIN-----------------TW-VSGNIVSSVAGNVAPYKWRWGYG-----IFCIIVP 232

  Fly   191 ---FVQESPHYYLRKNNMASLEKSLRWYRG-IRDIDDREKPEYLSE-LNEFHAELRSRDKNVGST 250
               .:...|:.|         .:.:.|..| :..:..:||.:.|.: |.:|     :.|.|:
Yeast   233 ISTLILVLPYVY---------AQYISWRSGKLPPLKLKEKGQTLRQTLWKF-----ADDINL--- 280

  Fly   251 PMSHGYIIRLTFVSFLLTVCAKLSGVFVELNYAADFLGRTGYSTETNYV-VLASAQCAGAL---- 310
               .|.|:   |.:||:.       |.:.|..|.   |.|....|.:.: ::....|.|.:
Yeast   281 ---IGVIL---FTAFLVL-------VLLPLTIAG---GATSKWREGHIIAMIVVGGCLGFIFLIW 329

  Fly   311 -LARLVGPRLPRKLLLCLSSLFAAAAVIALALFKAYGHLWLLGNWAD-RYLPIILLAIQLALVSF 373
             |.....|.:||        ::.....|.:||...:  :|.||...: .||..:|      :|:|
Yeast   330 ELKFAKNPFIPR--------VYLGDPTIYVALLMEF--VWRLGLQIELEYLVTVL------MVAF 378

  Fly   374 GLYPLAAVVSSEVLPTKLHDLLYSLASAVSWLLLFGMIEAFNAVKATIAPGLLLYLW----VFAG 434
            |...|:|...::     |::.|.|..:                    |..|::|:.:    ||..
Yeast   379 GESTLSAQRIAQ-----LYNFLQSCTN--------------------IVVGIMLHFYPHPKVFVV 418

  Fly   435 ASIFVGLISLPLLPETRNRRPSAVQRELGYVDDG-----------GVAKG-----------SAVT 477
            |...:|:|.:.||.:.|            .|.||           |:|.|           ::.|
Yeast   419 AGSLLGVIGMGLLYKYR------------VVYDGISGLIGAEIVVGIAGGMIRFPMWTLVHASTT 471

  Fly   478 NGHIAT 483
            :..:||
Yeast   472 HNEMAT 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	29/149 (19%)
CG8837	NP_001285582.1	Sugar_tr	58..453	CDD:278511	83/417 (20%)
ENB1	NP_014484.1	MFS_ARN_like	63..574	CDD:340880	105/526 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900