DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8837 and HXT8

DIOPT Version :9

Sequence 1:	NP_001285582.1	Gene:	CG8837 / 33545	FlyBaseID:	FBgn0031520	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_012321.1	Gene:	HXT8 / 853216	SGDID:	S000003750	Length:	569	Species:	Saccharomyces cerevisiae

Alignment Length:	508	Identity:	117/508 - (23%)
Similarity:	183/508 - (36%)	Gaps:	114/508 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCLPKRVGG-PAIQSVATALGNILCFNFGLMFG-ITPAHMTLYESEERTPLNQATDPAGTAWLTG 63
            |||....|| .:.....|..|.:...:|...|| .:.:..|.|.|..||.|..:....|:|  .|
Yeast    69 MCLCMAFGGFMSGWDTGTISGFVNQTDFLRRFGNYSHSKNTYYLSNVRTGLIVSIFNVGSA--IG 131

  Fly    64 YLFLSAALGALVSGFLALKIGPKSVLLCSGLL----QISGWACIHFGYDIVHIYASRLFAGVASG 124
            .|||| .||.:....:.|.|  ..|:...|::    .|..|    :.|     :..|:.||:.:|
Yeast   132 CLFLS-KLGDIYGRCMGLII--VIVVYMVGIVIQIASIDKW----YQY-----FIGRIIAGIGAG 184

  Fly   125 AAFVVLPIFINEIAESREKAARLTFTIELWR---TLGILIGFV-----------------LGFYV 169
            :..|:.|:.|:|.|....:...|.    .|:   |..|.:|:.                 ||...
Yeast   185 SISVLAPMLISETAPKHIRGTLLA----CWQLMVTFAIFLGYCTNYGTKTYSNSVQWRVPLGLCF 245

  Fly   170 PYAFVNIVGCAVSFVFTMTFPFVQESPHYYLRKNNM----ASLEKSLRWYRGIRDIDDREKPEYL 230
            .:|.:.|.|        ||  ||.|||.:.::...:    ||..||.:     ..:||   |..:
Yeast   246 AWAIIMIGG--------MT--FVPESPRFLVQVGKIEQAKASFAKSNK-----LSVDD---PAVV 292

  Fly   231 SELNEFHA--------------ELRSRDKNVGSTPMSHGYIIRLTFVSFLLTVCAKLSGVFVELN 281
            :|::...|              ||.||...|         ..||| ::.::....:|:|......
Yeast   293 AEIDLLVAGVEAEEAMGTASWKELFSRKTKV---------FQRLT-MTVMINSLQQLTGDNYFFY 347

  Fly   282 YAADFLGRTGY--STETNYVVLASAQCAGALLARLVGPRLPRKLLLCLSSLFAAAAVIALALFKA 344
            |........|.  |.||: :||.....|....:.....:|.|:..|.|.   ||.....:.::.:
Yeast   348 YGTTIFKSVGMNDSFETS-IVLGIVNFASCFFSLYSVDKLGRRRCLLLG---AATMTACMVIYAS 408

  Fly   345 YGHLWLLGNWADR-------YLPIILLAIQLALVSFGLYPLAAVVSSEVLPTKLHDLLYSLASAV 402
            .|...|..|....       ...|:.....:...|....|:..|:.||..|.::.....|:|:|.
Yeast   409 VGVTRLYPNGKSEPSSKGAGNCTIVFTCFYIFCFSCTWGPVCYVIISETFPLRVRSKCMSVATAA 473

  Fly   403 S--WLLLFGMIEAF--NAVKATIAPGLLLYLWVFAGASIFVGLISLPLLPETR 451
            :  |..|.|....|  :|:.       ..|.:||.|...|........:|||:
Yeast   474 NLLWGFLIGFFTPFITSAIN-------FYYGYVFMGCLAFSYFYVFFFVPETK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	37/161 (23%)
CG8837	NP_001285582.1	Sugar_tr	58..453	CDD:278511	100/449 (22%)
HXT8	NP_012321.1	Sugar_tr	69..530	CDD:395036	117/508 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830