DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8837 and VPS73

DIOPT Version :9

Sequence 1:	NP_001285582.1	Gene:	CG8837 / 33545	FlyBaseID:	FBgn0031520	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_011411.3	Gene:	VPS73 / 852774	SGDID:	S000003072	Length:	486	Species:	Saccharomyces cerevisiae

Alignment Length:	522	Identity:	108/522 - (20%)
Similarity:	183/522 - (35%)	Gaps:	124/522 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IQSVATALGNI-------------LCFNF------GLMFG-----ITPAHMTLYESEERTPLNQA 52
            |.|.|:.|.|:             ||:..      .:.||     :......|..||...|:...
Yeast     4 ILSSASLLSNVSMPRQNKHKITKALCYAIIVASIGSIQFGYHLSELNAPQQVLSCSEFDIPMEGY 68

  Fly    53 TDPAGTAWL-------------------TGYLFLSAALGALVSGFLALKIGPKSVLLCSGLLQIS 98
              |....||                   |....:...||:..:..||...|.|...|.:..|.|.
Yeast    69 --PYDRTWLGKRGYKQCIPLNDEQIGIVTSVFCIGGILGSYFATSLANIYGRKFSSLINCTLNIV 131

  Fly    99 GWACIHFGYDIVHIYASRLFAGVASGAAFVVLPIFINEIAESREKAARLTFTIELWRTLGILI-- 161
            |...|........:...|:..|::.|:..|::|:||.|:|.|..:....:.| ::...||:|:
Yeast   132 GSLIIFNSNSYRGLIIGRILVGISCGSLIVIIPLFIKEVAPSGWEGLLGSMT-QICIRLGVLLTQ 195

  Fly   162 GFVLGFYVPYAFVNIV-GCAVSFV-----FTMTFPFVQESPHYYLRKNNMASLEKSLRWYRGIRD 220
            |..|.....|.:..|: |   ||:     |.|.| .|.|||.:.|....:...:.||...||: .
Yeast   196 GIALPLTDSYRWRWILFG---SFLIAVLNFFMWF-IVDESPKWLLAHGRVTDAKLSLCKLRGV-T 255

  Fly   221 IDDREKPEYLSELNEFHAELRSRDKNVGSTPMSH--------GYIIRLTFVSFLLTVCAKLSGVF 277
            .|     |...|:.::..::.|.|..:..|..:.        .|:...|.|        |...|.
Yeast   256 FD-----EAAQEIQDWQLQIESGDPLIEPTTTNSISGSNSLWKYLRDRTNV--------KSRHVI 307

  Fly   278 VELNYAADFLGRTGYSTETNYVVLASAQCAGAL---------------------LARLVGPRLPR 321
            ..|.:...|.|       .|.:||...:....|                     |..|:...|||
Yeast   308 TVLLFGQQFCG-------INSIVLYGTKIISQLYPQHAIRINFFISMVNVLVTILVSLLIHSLPR 365

  Fly   322 KLLLCLSSLFAAAAVIALALFKAYGHLWLLGNWADRYLPIILLAIQLALVSFGLYPLAAVVSSEV 386
            |.||..|::..:.....:.:...:..:.||         |:...|.:.:.:.||.||..::..||
Yeast   366 KPLLMTSTVLVSVTAFIMGIAMNHNKMNLL---------IVFSFIYMGVFTMGLNPLPFIIMREV 421

  Fly   387 LPTKLHDLLYS--LASAVSWLLLFGMIEAFNAVKATIAPGLLLYLWVFAGASIFVGLISLPLLPE 449
              :|..|::.:  ..:..:|:..|.:...|..:...::..:.:   :||..:..:.......:||
Yeast   422 --SKPQDMVLAQRYGTICNWVGTFIIAYTFPIIHDVLSGYVFI---IFAIIACSISAFIWKKVPE 481

  Fly   450 TR 451
            |:
Yeast   482 TK 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	39/164 (24%)
CG8837	NP_001285582.1	Sugar_tr	58..453	CDD:278511	94/452 (21%)
VPS73	NP_011411.3	MFS_GLUT_Class1_2_like	31..484	CDD:340915	101/495 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840