DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8837 and MAL31

DIOPT Version :9

Sequence 1:	NP_001285582.1	Gene:	CG8837 / 33545	FlyBaseID:	FBgn0031520	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_009857.1	Gene:	MAL31 / 852601	SGDID:	S000000502	Length:	614	Species:	Saccharomyces cerevisiae

Alignment Length:	535	Identity:	109/535 - (20%)
Similarity:	173/535 - (32%)	Gaps:	187/535 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 ESEERTPLNQA--TDPAGTAWLTGYLFLSAAL------GALVSGFLALKIGPK------------ 86
            |||...||..|  |.|...||   .|.:|..|      .|::..|.||.:..|
Yeast    82 ESERGMPLMTALKTYPKAAAW---SLLVSTTLIQEGYDTAILGAFYALPVFQKKYGSLNSNTGDY 143

  Fly    87 --SVLLCSGL-----------LQISGWACIHFG--YDIVH-----------IYASRLFAGVASGA 125
              ||....||           ||::|.:..:.|  |.::.           :|..:....:|.|.
Yeast   144 EISVSWQIGLCLCYMAGEIVGLQMTGPSVDYMGNRYTLIMALFFLAAFIFILYFCKSLGMIAVGQ 208

  Fly   126 AFVVLP---------IFINEIAESREKAARLTFTIELWR-----TLGIL-------IGFVLGFYV 169
            |...:|         .:.:||.....:....|::...|.     ..||:       ....||:.:
Yeast   209 ALCGMPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWAFGQLFAAGIMKNSQNKYANSELGYKL 273

  Fly   170 PYAFVNI--VGCAVSFVFTMTFPFVQESPHYYLRKNNMASLEKSLRWYRGIRDIDDR--EKPEYL 230
            |:|...|  :..||. :|     |..|||.:.::|..:....:||.     |.:..:  ||...:
Yeast   274 PFALQWIWPLPLAVG-IF-----FAPESPWWLVKKGRIDQARRSLE-----RTLSGKGPEKELLV 327

  Fly   231 S-ELNE----FHAELRSRDKNVGSTPMSHGYIIRLTFVSFLLTVCAKLSGVFVELNYAADFLGRT 290
            | ||::    ...|.:..|:......:..|...|.|.::.|..:.....|..: :.|:..|..:.
Yeast   328 SMELDKIKTTIEKEQKMSDEGTYWDCVKDGINRRRTRIACLCWIGQCSCGASL-IGYSTYFYEKA 391

  Fly   291 GYSTETNYVVLASAQCAGALLARLVGPRLPRKLLLCLSSLFAAAAVIALALFKAYGHLWLLGNWA 355
            |.||:|.:.......|.|                       .||..|:          |    ||
Yeast   392 GVSTDTAFTFSIIQYCLG-----------------------IAATFIS----------W----WA 419

  Fly   356 DRY-----LPIILLAIQ-------------------------LALVSF----GLYPLAAVVSSEV 386
            .:|     |....||.|                         |.:|:|    |:.|:...:.||:
Yeast   420 SKYCGRFDLYAFGLAFQAIMFFIIGGLGCSDTHGAKMGSGALLMVVAFFYNLGIAPVVFCLVSEI 484

  Fly   387 LPTKLHDLLYSLASAVSWLLLFGMIEAFNAVKATIAPGLLLY-----LWVFAGASIFV--GLISL 444
            ..::|......||.           .|:|.::..:.. |::|     .|.:...|.|.  |....
Yeast   485 PSSRLRTKTIILAR-----------NAYNVIQVVVTV-LIMYQLNSEKWNWGAKSGFFWGGFCLA 537

  Fly   445 PL------LPETRNR 453
            .|      ||||..|
Yeast   538 TLAWAVVDLPETAGR 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	39/204 (19%)
CG8837	NP_001285582.1	Sugar_tr	58..453	CDD:278511	100/515 (19%)
MAL31	NP_009857.1	SP	74..557	CDD:273317	109/535 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342346
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830