DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8837 and ITR1

DIOPT Version :9

Sequence 1:	NP_001285582.1	Gene:	CG8837 / 33545	FlyBaseID:	FBgn0031520	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_010785.1	Gene:	ITR1 / 852108	SGDID:	S000002905	Length:	584	Species:	Saccharomyces cerevisiae

Alignment Length:	497	Identity:	108/497 - (21%)
Similarity:	182/497 - (36%)	Gaps:	88/497 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GLMFG-----ITPAHMTLYESEERTPLNQATDPAGTAWLTGYLFLSAALGALV----SGFLALKI 83
            |.|||     |:.|.:::....:...|........||        :.:||||:    :|..|...
Yeast    97 GFMFGYDTGYISSALISIGTDLDHKVLTYGEKEIVTA--------ATSLGALITSIFAGTAADIF 153

  Fly    84 GPKSVLLCSGLLQISGWACIHFGYDIVHIYASRLFAGVASGAAFVVLPIFINEIAESREKAARLT 148
            |.|..|:.|.|:.:.|.......:....:...||..|...|...::.|:||:|||....: .|||
Yeast   154 GRKRCLMGSNLMFVIGAILQVSAHTFWQMAVGRLIMGFGVGIGSLIAPLFISEIAPKMIR-GRLT 217

  Fly   149 FTIELWRTLGILIGFVLGFYVPY--------AFVNIVGCAVSFVFTMTFPFVQESPHYYLRKNNM 205
            ....||.|.|.|:.:..|..:.|        ..::::..||.|.   ...|:.::|.||:.|.::
Yeast   218 VINSLWLTGGQLVAYGCGAGLNYVNNGWRILVGLSLIPTAVQFT---CLCFLPDTPRYYVMKGDL 279

  Fly   206 ASLEKSLRWYRGIRDIDD---REKPEYLSELNE------FHAELRSRDKNVGSTPMSHGYIIRLT 261
            |...:.|:  |...|..:   ..|.|.|..||:      ...::.:..|.:.:.|.:    :|..
Yeast   280 ARATEVLK--RSYTDTSEEIIERKVEELVTLNQSIPGKNVPEKVWNTIKELHTVPSN----LRAL 338

  Fly   262 FVSFLLTVCAKLSGVFVELNYAADFLGRTGYSTE---------TNY----VVLASAQCAGALLAR 313
            .:...|....:.:|....:.::.......|:...         ||:    |...|....|.....
Yeast   339 IIGCGLQAIQQFTGWNSLMYFSGTIFETVGFKNSSAVSIIVSGTNFIFTLVAFFSIDKIGRRTIL 403

  Fly   314 LVG-PRLPRKLLLC------LSSLF-AAAAVIALALFKAYGHLWLLGNWADRYLPIILLAIQLAL 370
            |:| |.:...|::|      |...| .|.||:..:.|.::|              |:::...:..
Yeast   404 LIGLPGMTMALVVCSIAFHFLGIKFDGAVAVVVSSGFSSWG--------------IVIIVFIIVF 454

  Fly   371 VSFGLYPLAAV--VSSEVLPTKLHDLLYSLASAVSWLLLFGMIEAFNAVKATIAP-GLLLYLWVF 432
            .:|....:..|  ..||:.|..:..:..|.|:|.:|.....:...|..:...|.| |...:   |
Yeast   455 AAFYALGIGTVPWQQSELFPQNVRGIGTSYATATNWAGSLVIASTFLTMLQNITPAGTFAF---F 516

  Fly   433 AGASIFVGLISLPLLPETRNRRPSAVQRELGYVDDGGVAKGS 474
            ||.|....:......||........||..|   .||...|.|
Yeast   517 AGLSCLSTIFCYFCYPELSGLELEEVQTIL---KDGFNIKAS 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	37/149 (25%)
CG8837	NP_001285582.1	Sugar_tr	58..453	CDD:278511	94/439 (21%)
ITR1	NP_010785.1	MFS_HMIT_like	92..533	CDD:340918	99/470 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740