Protein Alignment CG8837 and SLC2A3

DIOPT Version :9

• Sequence 1: NP_001285582.1
• Gene: CG8837 / 33545
• FlyBaseID: FBgn0031520
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Alignment Length: 495
• Identity: 102/495 - (20%)
• Similarity: 186/495 - (37%)
• Gaps: 108/495 - (21%)

  Fly    16 ATALGNILCFNFGLMFGITPA-HMTLYESEERTPLNQATDPAGTAWLTGYLFLSAA-------LG 72
            |..:..|..|.||...|:..| ...:.|...:|..::...|.....||....||.|       :|
Human    13 AITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIG 77

  Fly    73 ALVSGFLALKIGPKSVLLCSGLLQISGWACI----HFGYDIVHIYASRLFAGVASGAAFVVLPIF 133
            :...|....:.|.::.:|...||.::| .|.    .....:..:...||..|:..|.....:|::
Human    78 SFSVGLFVNRFGRRNSMLIVNLLAVTG-GCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMY 141

  Fly   134 INEIAESREKAARLTFTIELWRTLGILIG------FVLGFYVPYAFVNIVGCAV--SFVFTMTFP 190
            |.||:.:..:.|..|.. :|...:|||:.      |:||....:..  ::|..:  :.:.:...|
Human   142 IGEISPTALRGAFGTLN-QLGIVVGILVAQIFGLEFILGSEELWPL--LLGFTILPAILQSAALP 203

  Fly   191 FVQESPHYYL-RKNNMASLEKSLRWYRGIRDIDDREKPEYLSELNEFHAELRSRDKNVGSTPMSH 254
            |..|||.:.| .:....:.::.|:...|.:|:.     :.:.|:.:..|.: |::|.|  |.:.
Human   204 FCPESPRFLLINRKEEENAKQILQRLWGTQDVS-----QDIQEMKDESARM-SQEKQV--TVLE- 259

  Fly   255 GYIIRLT------FVSFLLTVCAKLSGVFVELNYAADFLGRTGYSTETNYVVLASAQCAGALLAR 313
              :.|::      .:|.:|.:..:|||:.....|:.......|.. |..|..:.    ||.
Human   260 --LFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQ-EPIYATIG----AGV---- 313

  Fly   314 LVGPRLPRKLLLCLSSLFAAAAVIALALFKAYG----HLWLLGNWA-------------DRY--L 359
                         ::::|   .|::|.|.:..|    |:..||..|             |.|  :
Human   314 -------------VNTIF---TVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGM 362

  Fly   360 PIILLAIQLALVSF---GLYPLAAVVSSEVLPTKLHDLLYSLASAVSWLLLFGMIEAFNAVKATI 421
            ..:.:...|..|:|   |..|:...:.:|:..........::|...:|        ..|.:...:
Human   363 SFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNW--------TSNFLVGLL 419

  Fly   422 APGLLLYL--WVFAGASIFVGLISLPL------LPETRNR 453
            .|....||  :||.   ||.|.:...|      :||||.|
Human   420 FPSAAHYLGAYVFI---IFTGFLITFLAFTFFKVPETRGR 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	33/156 (21%)
		Sugar_tr	58..453	CDD:278511	91/450 (20%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	101/493 (20%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)
		Monosaccharide binding. /evidence=ECO:0000269|PubMed:26176916	280..286		3/5 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143937
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840