Protein Alignment CG8837 and SLC2A1

DIOPT Version :9

• Sequence 1: NP_001285582.1
• Gene: CG8837 / 33545
• FlyBaseID: FBgn0031520
• Length: 485
• Species: Drosophila melanogaster
• Sequence 2: NP_006507.2
• Gene: SLC2A1 / 6513
• HGNCID: 11005
• Length: 492
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 104/491 - (21%)
• Similarity: 187/491 - (38%)
• Gaps: 80/491 - (16%)

  Fly     5 KRVGGPAIQSVATA-LGNILCFNFGLMFGITPA-HMTLYESEERTPLNQATDPAGTAWLTGYLFL 67
            |::.|..:.:|..| ||::   .||...|:..| ...:.|...:|.:::..:......||....|
Human     6 KKLTGRLMLAVGGAVLGSL---QFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTTLTTLWSL 67

  Fly    68 SAA-------LGALVSGFLALKIGPKSVLLCSGLLQISGWACIHF---GYDIVHIYASRLFAGVA 122
            |.|       :|:...|....:.|.::.:|...||.......:.|   |.....:...|...||.
Human    68 SVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVY 132

  Fly   123 SGAAFVVLPIFINEIAESREKAARLTFTIELWRTLGIL--IGFVLGFYVPYAF--VNIVG----- 178
            .|.....:|:::.|::.:..:.|           ||.|  :|.|:|..:...|  .:|:|
Human   133 CGLTTGFVPMYVGEVSPTALRGA-----------LGTLHQLGIVVGILIAQVFGLDSIMGNKDLW 186

  Fly   179 -CAVSFVF------TMTFPFVQESPHYYLRKNNMASLEKS-LRWYRGIRDIDDREKPEYLSELNE 235
             ..:|.:|      .:..||..|||.:.|...|..:..|| |:..||..|:        ..:|.|
Human   187 PLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADV--------THDLQE 243

  Fly   236 FHAELRS--RDKNVGSTPMSHGYIIRL-TFVSFLLTVCAKLSGVFVELNYAADFLGRTGYSTETN 297
            ...|.|.  |:|.|....:......|. ..::.:|.:..:|||:.....|:.....:.|.. :..
Human   244 MKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQ-QPV 307

  Fly   298 YVVLAS--AQCAGALLARLVGPRLPRKL--LLCLSSLFAAAAVIALALFKAYGHLWLLGNWADRY 358
            |..:.|  ...|..:::..|..|..|:.  |:.|:.:...|.::.:||.......|:      .|
Human   308 YATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQLPWM------SY 366

  Fly   359 LPIILLAIQLALVSFGLYPLAAVVSSEVLPTKLHDLLYSLASAVSWLLLFGMIEAFNAVKATIAP 423
            |.|:.:...:|....|..|:...:.:|:..........::|...:|...|.:...|..|:....|
Human   367 LSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGP 431

  Fly   424 GLLLYLWVFAGASIFVGLISLPLL------PETRNR 453
                |:::     ||..|:.|..:      |||:.|
Human   432 ----YVFI-----IFTVLLVLFFIFTYFKVPETKGR 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	32/163 (20%)
		Sugar_tr	58..453	CDD:278511	91/434 (21%)
SLC2A1	NP_006507.2	MFS_GLUT_Class1	14..458	CDD:340989	101/481 (21%)
		Monosaccharide binding. /evidence=ECO:0000269|PubMed:24847886	282..288		3/5 (60%)
		Disordered. /evidence=ECO:0000305|PubMed:30197081	468..492

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840