DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8837 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_001285582.1	Gene:	CG8837 / 33545	FlyBaseID:	FBgn0031520	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_062361.1	Gene:	Slc2a8 / 56017	MGIID:	1860103	Length:	477	Species:	Mus musculus

Alignment Length:	475	Identity:	112/475 - (23%)
Similarity:	201/475 - (42%)	Gaps:	70/475 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IQSVATALGNILCFNFGLMFGITPAHMTLYESEERTPLNQATDPA------GTAWLTGYLFLSAA 70
            :.|.|.|||.:   :||...|        |.|.....|.:...||      ..:|....:.|.||
Mouse    28 LASFAAALGPL---SFGFALG--------YSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAA 81

  Fly    71 LGALVSGFLALKIGPK-SVLLCSGLLQISGWACIHFGYDIVHIYASRLFAGVASGAAFVVLPIFI 134
            .|.::.|:|..:.|.| |:|||: :..::|:|.|....|:..:...||..|:|.|.|.:|.|::|
Mouse    82 AGGILGGWLLDRAGRKLSLLLCT-VPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYI 145

  Fly   135 NEIAESREKAARLTFTIELWRTLGILIGFVLGFYVPYAFVNIVGCAVSFVFTMTFPFVQESPHYY 199
            :|||....:.. |...::|....|||:.:|.|:.:.:.::.::||....:..:...::.|:|.:.
Mouse   146 SEIAYPAVRGL-LGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFL 209

  Fly   200 LRKNNMASLEKSLRWYRGIRDIDDREKPEYLSELNEFHAELRSRDKNVGSTPMSHGYIIRLTFVS 264
            |.::.......:||:..|..  :..|:|...:|...|...|..|..           |.:...:.
Mouse   210 LTQHQYQEAMAALRFLWGSE--EGWEEPPVGAEHQGFQLALLRRPG-----------IYKPLIIG 261

  Fly   265 FLLTVCAKLSGVFVELNYAADFLGRTGYSTETNYVVLASA-----QCAGALLARLVGPRLPRKLL 324
            ..|.|..:||||...:.||........:...:    |||.     |.....:|.|:..|..|:||
Mouse   262 ISLMVFQQLSGVNAIMFYANSIFEEAKFKDSS----LASVTVGIIQVLFTAVAALIMDRAGRRLL 322

  Fly   325 LCLSSLFAAAAVIALALFKAY-----------GHLWLLGNWAD--------RYLPIILLAIQLAL 370
            |.||.:.   .|.:::.|..|           .|:.|:...|:        .:|.:..:.:.:|.
Mouse   323 LALSGVI---MVFSMSAFGTYFKLTQSLPSNSSHVGLVPIAAEPVDVQVGLAWLAVGSMCLFIAG 384

  Fly   371 VSFGLYPLAAVVSSEVLPTKLHDLLYSLASAVSWLLLFGMIEAFNAVKATIAPGLLLY--LWVFA 433
            .:.|..|:..::.||:.|..:..:...:....:|.:.|.:.:.|::|...:.|    |  .|:.|
Mouse   385 FAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWFMAFLVTKEFSSVMEMLRP----YGAFWLTA 445

  Fly   434 GASIFVGLISLPLLPETRNR 453
            .......|.:|.::|||:.|
Mouse   446 AFCALSVLFTLTVVPETKGR 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	40/144 (28%)
CG8837	NP_001285582.1	Sugar_tr	58..453	CDD:278511	98/421 (23%)
Slc2a8	NP_062361.1	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:16723738	12..13
		Sugar_tr	29..474	CDD:278511	112/474 (24%)
		MFS	31..459	CDD:119392	107/464 (23%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834211
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740