DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8837 and Slc2a1

DIOPT Version :9

Sequence 1:	NP_001285582.1	Gene:	CG8837 / 33545	FlyBaseID:	FBgn0031520	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_620182.1	Gene:	Slc2a1 / 24778	RGDID:	3704	Length:	492	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	106/495 - (21%)
Similarity:	183/495 - (36%)	Gaps:	88/495 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KRVGGPAIQSVATA-LGNILCFNFGLMFGITPAHMTLYES----------EERTPLNQATDPAGT 58
            |:|.|..:.:|..| ||::   .||...|:..|...:.|.          .|..|....|    |
  Rat     6 KKVTGRLMLAVGGAVLGSL---QFGYNTGVINAPQKVIEEFYNQTWNHRYGESIPSTTLT----T 63

  Fly    59 AWLTGYLFLSAA--LGALVSGFLALKIGPKSVLLCSGLLQISGWACIHF---GYDIVHIYASRLF 118
            .|.......|..  :|:...|....:.|.::.:|...||.......:.|   |.....:...|..
  Rat    64 LWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFI 128

  Fly   119 AGVASGAAFVVLPIFINEIAESREKAARLTFTIELWRTLGIL--IGFVLGFYVPYAF--VNIVGC 179
            .||..|.....:|:::.|::.:..:.|           ||.|  :|.|:|..:...|  .:|:|.
  Rat   129 IGVYCGLTTGFVPMYVGEVSPTALRGA-----------LGTLHQLGIVVGILIAQVFGLDSIMGN 182

  Fly   180 A------VSFVF------TMTFPFVQESPHYYLRKNNMASLEKS-LRWYRGIRDIDDREKPEYLS 231
            |      :|.:|      .:..||..|||.:.|...|..:..|| |:..||..|:        ..
  Rat   183 ADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTADV--------TR 239

  Fly   232 ELNEFHAELRS--RDKNVGSTPMSHGYIIRL-TFVSFLLTVCAKLSGVFVELNYAADFLGRTGYS 293
            :|.|...|.|.  |:|.|....:......|. ..::.:|.:..:|||:.....|:.....:.|..
  Rat   240 DLQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQ 304

  Fly   294 TETNYVVLAS--AQCAGALLARLVGPRLPRKL--LLCLSSLFAAAAVIALALFKAYGHLWLLGNW 354
             :..|..:.|  ...|..:::..|..|..|:.  |:.|:.:...|.::.:||.......|:
  Rat   305 -QPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLEQLPWM---- 364

  Fly   355 ADRYLPIILLAIQLALVSFGLYPLAAVVSSEVLPTKLHDLLYSLASAVSWLLLFGMIEAFNAVKA 419
              .||.|:.:...:|....|..|:...:.:|:..........::|...:|...|.:...|..|:.
  Rat   365 --SYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQ 427

  Fly   420 TIAPGLLLYLWVFAGASIFVGLISLPLL------PETRNR 453
            ...|    |:::     ||..|:.|..:      |||:.|
  Rat   428 LCGP----YVFI-----IFTVLLVLFFIFTYFKVPETKGR 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	31/158 (20%)
CG8837	NP_001285582.1	Sugar_tr	58..453	CDD:278511	90/429 (21%)
Slc2a1	NP_620182.1	MFS_GLUT_Class1	14..458	CDD:340989	102/485 (21%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	282..288		3/5 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337786
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930