DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8837 and AgaP_AGAP008900

DIOPT Version :9

Sequence 1:	NP_001285582.1	Gene:	CG8837 / 33545	FlyBaseID:	FBgn0031520	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	XP_319647.4	Gene:	AgaP_AGAP008900 / 1279867	VectorBaseID:	AGAP008900	Length:	480	Species:	Anopheles gambiae

Alignment Length:	464	Identity:	134/464 - (28%)
Similarity:	225/464 - (48%)	Gaps:	35/464 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PAIQSVA--TALGNILCFNFGLMFGITPAHMTLYESEERTPLNQ--ATDPAGTAWLTGYLFLSAA 70
            |::.|::  :...||:..:.|...|.....:.|..|.: :||:|  .||...| |:...|.:.|.
Mosquito    17 PSLPSLSNPSPAANIISLSLGTAIGWLSPFLPLLISTD-SPLDQGPVTDVQAT-WIASLLCIGAF 79

  Fly    71 LGALVSGFLALKIGPKSVLLCSGLLQISGWACIHFGYDIVHIYASRLFAGVASGAAFVVLPIFIN 135
            .|.|:.|:.|.|.|.|:.||.:.:..|..|.|:.||..:..:|.:||.||:.:...|:::|::|.
Mosquito    80 GGTLLFGWSAEKFGRKASLLATAVPLICFWGCVAFGTTVEVLYVARLLAGLGAAGVFLLVPMYIT 144

  Fly   136 EIAESREKAARLTFTIELWRTLGILIGFVLGFYVPYAFVNIVGCAVSFVFTMTFPFVQESPHYYL 200
            ||||.|.:....:|.| |:..:|.|:.||:|.|:.|.....:...:..||...|....|:|.|.:
Mosquito   145 EIAEDRIRGTLGSFFI-LFLNIGTLVSFVMGSYLSYHTTAYILFTLPIVFLALFLQFPETPQYLI 208

  Fly   201 RKNNMASLEKSLRWYRGIRDIDDREKPEYL----SELN----EFHAELRSRDKN--VGSTPMSHG 255
            |:|.:...|.||::.||.     ...|::|    ||::    :...|..|.::|  :.....:..
Mosquito   209 RRNRVRDAESSLKYLRGY-----TSTPDHLEMLRSEMDGLLVQVSGEKDSTEQNSRISLADFAPP 268

  Fly   256 YIIRLTFVSFLLTVCAKLSGVFVELNYAADFLGRTGYSTETNY--VVLASAQCAGALLARLVGPR 318
            ...:...:..:|....:|||.|..:||.|......|...:.|.  :|:.:.|..|:..:.::..|
Mosquito   269 SARKALLIGLVLVSLNQLSGCFALINYTAQIFADAGSDLDPNMAAIVVGAIQIIGSYGSTIIVDR 333

  Fly   319 LPRKLLLCLSSLFAAAAVIALALFKAYGHLWLLGNWAD----RYLPIILLAIQLALVSFGLYPLA 379
            .|||.|..:||.||     |:.||....|.:|.....|    .::|:..|:..:.:.|.||.||.
Mosquito   334 CPRKHLYIVSSFFA-----AIGLFAMGTHGYLKSQHVDVSAINWIPVASLSFVIFIASVGLLPLT 393

  Fly   380 AVVSSEVLPTKLHDLLYSLASAVSWLLLFGMIEAFNAVKATIAPGLLLYLWVFAGASIFVGLISL 444
            .|:.||:||.|:..|..|:.:|..|::.|.:::.|..:...|  ||...:|||:...:..||.:.
Mosquito   394 FVILSEILPPKVRGLGGSICTAFLWMISFLVVKYFPVMVELI--GLHGCMWVFSAVCLSAGLFNA 456

  Fly   445 PLLPETRNR 453
            ..:||||.|
Mosquito   457 IFIPETRGR 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8837	NP_001285582.1	MFS	54..>192	CDD:119392	45/137 (33%)
CG8837	NP_001285582.1	Sugar_tr	58..453	CDD:278511	120/410 (29%)
AgaP_AGAP008900	XP_319647.4	MFS	31..454	CDD:119392	125/437 (29%)
AgaP_AGAP008900	XP_319647.4	2A0114	62..459	CDD:273326	118/410 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004527
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810