Protein Alignment Fign and VPS4B

DIOPT Version :10

• Sequence 1: NP_608763.2
• Gene: Fign / 33544
• FlyBaseID: FBgn0031519
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_004860.2
• Gene: VPS4B / 9525
• HGNCID: 10895
• Length: 444
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 149/456 - (32%)
• Similarity: 234/456 - (51%)
• Gaps: 59/456 - (12%)

  Fly   109 VSSTYP-VQQAVKSRPEGQFPESRNNSTKKIDAQQYSSESSSQSGFGFRTAREQLIMDELKKKNR 172
            :|||.| :|:|:....:....:...|..:.:...|::.:      :.....:.:...|:.|:..|
Human     1 MSSTSPNLQKAIDLASKAAQEDKAGNYEEALQLYQHAVQ------YFLHVVKYEAQGDKAKQSIR 59

  Fly   173 QATSE----VDAVPTGMMNFRKKTLGGKRTVSSNFVSPVAQNDNSTSSRSSSIPPALAHLDSKMV 233
            ...:|    .:.:...:.|..||   .::.|.....||..:..|.:.....|..|....|.:::.
Human    60 AKCTEYLDRAEKLKEYLKNKEKK---AQKPVKEGQPSPADEKGNDSDGEGESDDPEKKKLQNQLQ 121

  Fly   234 DHILGESMHDFKP-VAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKT 297
            ..|:.|     :| |.|.|:||||.||....||:|:|::.|.||||.|.|.||:||||||||||:
Human   122 GAIVIE-----RPNVKWSDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKS 181

  Fly   298 LIAKSIASQA-KAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSAN 361
            .:||::|::| .:.||||:.|.|.|||:|::|||||.||.:|..::|:||||||:|||...||.|
Human   182 YLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSLCGSRSEN 246

  Fly   362 ENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDEAVRRRFVRRLYVPLPTREARQKII 426
            |:|:..|:|.|||:.:.|...:.: .:||:||||.|..||.|:||||.:|:|:|||...||..:.
Human   247 ESEAARRIKTEFLVQMQGVGVDND-GILVLGATNIPWVLDSAIRRRFEKRIYIPLPEPHARAAMF 310

  Fly   427 EKLIHQVKHNLDVRQVIELAELTDGYSGADVDTLCRYASMAPLRSL------------------- 472
            :..:...:::|......||...||||||||:..:.|.|.|.|:|.:
Human   311 KLHLGTTQNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQSATHFKKVRGPSRADPNH 375

  Fly   473 ---------TPDQMEVIETHQL---------PAVTMDDFKQALRVISKSVSSEDCKQFEAWNEIY 519
                     :|.....||...:         |.|:|.|..::|.....:|:..|..:.:.:.|.:
Human   376 LVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRSLSNTKPTVNEHDLLKLKKFTEDF 440

  Fly   520 G 520
            |
Human   441 G 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_608763.2	PH-like	<4..50	CDD:473070
		P-loop containing Nucleoside Triphosphate Hydrolases	229..414	CDD:476819	93/186 (50%)
		AAA_lid_3	444..495	CDD:465537	22/87 (25%)
		Vps4_C	<480..520	CDD:462762	10/48 (21%)
VPS4B	NP_004860.2	MIT_VPS4	6..81	CDD:239141	10/80 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..117		9/42 (21%)
		RecA-like_VPS4	128..298	CDD:410929	91/170 (54%)
		AAA_lid_3	325..366	CDD:465537	15/40 (38%)
		Vps4_C	381..441	CDD:462762	11/59 (19%)