DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fign and SAP1

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_010966.1	Gene:	SAP1 / 856771	SGDID:	S000000849	Length:	897	Species:	Saccharomyces cerevisiae

Alignment Length:	565	Identity:	182/565 - (32%)
Similarity:	284/565 - (50%)	Gaps:	87/565 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RSSSESIHFAALKDHHARLQACESME----------KAMKERCQKKITMSRRTKRGITHAGYLFE 74
            |:||.    .|||.|  .|:...:|:          |.||......:..::.|...||.:...|.
Yeast   352 RASST----GALKPH--SLETSTTMDSSKIRNPQISKLMKNNHVPYLKGTKSTPTLITKSTPTFI 410

  Fly    75 MPHNSVFEPECRGFYES-CQQTEMASSDLQAP------------ALEVSSTYPVQQAVKSRP--E 124
            ....|..:|..:....| .....:.:|.:|.|            :.:|:|...:....||.|  :
Yeast   411 TRSKSNTKPIIKSNASSPTSSLTVPNSVIQKPKTAAMAAKRVLNSKKVASNPALNTTKKSHPILK 475

  Fly   125 GQFPESRNNSTKKIDAQQYSSESSSQSGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFR 189
            .:..:..|:|:||..:.. |...|:...:....::.:      |....|.||         |:..
Yeast   476 SKTAKVPNSSSKKTSSHP-SRPVSNSKPYSHGASQNK------KPSKNQTTS---------MSKT 524

  Fly   190 KKTLGGKRTVSSNFVSPVAQNDNSTSSRSSSIPPALAHLDSKMVDHILGESMHDF---------- 244
            .:.:..::.:.|..:..|...|.:..:.|.:.......:|.|::..||.:.:.|.
Yeast   525 NRKIPAQKKIGSPKIEDVGTEDATEHATSLNEQREEPEIDKKVLREILEDEIIDSLQGVDRQAAK 589

  Fly   245 ----------KPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLI 299
                      ..|.|:|||||||||.:..||::.|..|||||.|:|.|.||:|||||||||||::
Yeast   590 QIFAEIVVHGDEVHWDDIAGLESAKYSLKEAVVYPFLRPDLFRGLREPVRGMLLFGPPGTGKTML 654

  Fly   300 AKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLL-SKRSANEN 363
            |:::|:::.:.||||:.||||||::|::||||:.|||:|....|:|||:||:||:: |:.:.|||
Yeast   655 ARAVATESHSTFFSISASSLTSKYLGESEKLVRALFAIAKKLSPSIIFVDEIDSIMGSRNNENEN 719

  Fly   364 ESTLRLKNEFLIH---LDGAAS---------------NEEIRVLVIGATNRPQELDEAVRRRFVR 410
            ||:.|:|||||:.   |..||:               .::.||||:.|||.|..:|||.||||||
Yeast   720 ESSRRIKNEFLVQWSSLSSAAAGSNKSNTNNSDTNGDEDDTRVLVLAATNLPWSIDEAARRRFVR 784

  Fly   411 RLYVPLPTREARQKIIEKLIHQVKHNLDVRQVIELAELTDGYSGADVDTLCRYASMAPLRSLTPD 475
            |.|:|||..:.|....:||:...||.|......||.::|:||||:|:.:|.:.|:|.|||.| .|
Yeast   785 RQYIPLPEDQTRHVQFKKLLSHQKHTLTESDFDELVKITEGYSGSDITSLAKDAAMGPLRDL-GD 848

  Fly   476 QMEVIETHQLPAVTMDDFKQALRVISKSVSSEDCKQFEAWNEIYG 520
            ::...|...:..:.:.|||.:|..|..|||.:...::|.|...:|
Yeast   849 KLLETEREMIRPIGLVDFKNSLVYIKPSVSQDGLVKYEKWASQFG 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	79/154 (51%)
		AAA	286..416	CDD:278434	74/148 (50%)
		Vps4_C	<480..520	CDD:286426	11/39 (28%)
SAP1	NP_010966.1	Herpes_BLLF1	<353..543	CDD:282904	38/211 (18%)
SAP1	NP_010966.1	SpoVK	<557..890	CDD:223540	139/333 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345775
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.600