Protein Alignment Fign and KATNAL2

DIOPT Version :10

• Sequence 1: NP_608763.2
• Gene: Fign / 33544
• FlyBaseID: FBgn0031519
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001340828.1
• Gene: KATNAL2 / 83473
• HGNCID: 25387
• Length: 564
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 169/583 - (28%)
• Similarity: 269/583 - (46%)
• Gaps: 147/583 - (25%)

  Fly    26 IHFAALKDHHARLQACESMEKAMKERCQKKITMSRRTKRGITHAGYLFEMPHNSVFEPECR-GF- 88
            :.:..||..|...:|||...:|.::.....|:      ..:|..||:   ...:..|.|.: |.
Human    29 LSYQTLKFTHQAREACEMRTEARRKNLLILIS------HYLTQEGYI---DTANALEQETKLGLR 84

  Fly    89 -YESCQQTEMASSDLQAPALEVSSTYPVQ-----QAVK---SRPEGQFPESRNNSTKKIDAQQYS 144
             :|.|.     :.||:...:|..|.|.|:     :.||   ...|...|:.....|:::
Human    85 RFEVCD-----NIDLETILMEYESYYFVKFQKYPKIVKKSSDTAENNLPQRSRGKTRRM------ 138

  Fly   145 SESSSQSGFGFRTAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGK------------- 196
            ...|.|:               |.|.|:|..             |.||..||
Human   139 MNDSCQN---------------LPKINQQRP-------------RSKTTAGKTGDTKSLNKEHPN 175

  Fly   197 -------RTVSSNF---VSPVAQNDNSTSSR-------------SSSIPPALAHLDSKMVDHILG 238
                   |..|:||   :|.:.::....::.             :.:|..|.:.|.....||...
Human   176 QEVVDNTRLESANFGLHISRIRKDSGEENAHPRRGQIIDFQGLLTDAIKGATSELALNTFDHNPD 240

  Fly   239 ESMHDFKP----------------------------VAWEDIAGLESAKSTFLEAIIMPLRRPDL 275
            .|....||                            :.|.||.||::||....||::.|:|.|.|
Human   241 PSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQL 305

  Fly   276 FTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAA 340
            |||:..|.:|:||:|||||||||:||::|::.|..||:|:.|::.|||.||:||||:.||.:|..
Human   306 FTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARY 370

  Fly   341 HQPAIIFIDEVDSLLSKR---SANENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDE 402
            |.|:.||:||::|::|:|   |..|:|.:||:|.|.|:.:||.|.:|:: |.|:.|:|.|.|||.
Human   371 HAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDL-VFVLAASNLPWELDC 434

  Fly   403 AVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHN--LDVRQVIE---LAELTDGYSGADVDTLCR 462
            |:.||..:|:.|.||:|||||.:|...:..|..:  |::...:|   |::.|:||||:|:..:||
Human   435 AMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCR 499

  Fly   463 YASMAPLRSLTPDQMEVIETHQ-----LPAVTMD-----DFKQALRVISKSVSSEDCKQFEAW 515
            .|:|.|:|.:    .:.:|.||     ||.:.:|     ||...| ..:|..:....:::..|
Human   500 EAAMRPVRKI----FDALENHQSESSDLPRIQLDIVTTADFLDVL-THTKPSAKNLAQRYSDW 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_608763.2	PH-like	<4..50	CDD:473070	7/23 (30%)
		P-loop containing Nucleoside Triphosphate Hydrolases	229..414	CDD:476819	87/215 (40%)
		AAA_lid_3	444..495	CDD:465537	22/63 (35%)
		Vps4_C	<480..520	CDD:462762	11/46 (24%)
KATNAL2	NP_001340828.1	LisH	51..81	CDD:128913	6/38 (16%)
		RPT1	212..548	CDD:440835	125/341 (37%)
		RecA-like_VPS4-like	282..446	CDD:410917	80/164 (49%)