DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fign and AFG2B

DIOPT Version :10

Sequence 1:NP_608763.2 Gene:Fign / 33544 FlyBaseID:FBgn0031519 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_076968.2 Gene:AFG2B / 79029 HGNCID:28762 Length:753 Species:Homo sapiens


Alignment Length:416 Identity:118/416 - (28%)
Similarity:193/416 - (46%) Gaps:79/416 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 TAREQLIMDELKKKNRQATSEVDAVPTGMMNFRKKTLGGKRTVSSNFVSPVAQN----------- 210
            |.|...:...|::..|.....|...||  :..||:.|   :.::|..  |::.:           
Human   344 TNRPDALDPALRRPGRFDREVVIGTPT--LKQRKEIL---QVITSKM--PISSHVDLGLLAEMTV 401

  Fly   211 -----DNSTSSRSSSIPPALAHLDSKMVDHILGE-------------------SMHDFKPVAWED 251
                 |.:...|.::: .||.|.:....:.::.|                   .:.|.|||.||:
Human   402 GYVGADLTALCREAAM-HALLHSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVIGLMDIKPVDWEE 465

  Fly   252 IAGLESAKSTFLEAIIMPLRRPDLFTGVR---CPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFS 313
            |.|||..|....::|..||:.|..|  ||   ..|:||||:||||..||.:.:::|:.....|.|
Human   466 IGGLEDVKLKLKQSIEWPLKFPWEF--VRMGLTQPKGVLLYGPPGCAKTTLVRALATSCHCSFVS 528

  Fly   314 INPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTL--RLKNEFLIH 376
            ::.:.|.|.:|||:||::..:|..|.|..|||:|:||:||:|..|||::....:  |:.:..|..
Human   529 VSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQERVLSVLLNE 593

  Fly   377 LDGA-----------ASNEEIR------VLVIGATNRPQELDEAVRR--RFVRRLYVPLPTREAR 422
            |||.           :|.:|.:      |::|.|||||..||.|:.|  |..:.:|:|.|..:.|
Human   594 LDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGR 658

  Fly   423 QKIIEKLIHQVKHNLDVRQVIELAELTDGYSGADVDTLCRYASMAPLRSLTPDQMEVIETHQLPA 487
            ..|::.....:....|| .:..||..|..:||||:..||..|::..|:....|...|.:.|    
Human   659 LSILKVCTKTMPIGPDV-SLENLAAETCFFSGADLRNLCTEAALLALQENGLDATTVKQEH---- 718

  Fly   488 VTMDDFKQALRVISKSVSSEDCKQFE 513
                 |.::|:.:..|:|.:|...:|
Human   719 -----FLKSLKTVKPSLSCKDLALYE 739

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FignNP_608763.2 PH-like <4..50 CDD:473070
P-loop containing Nucleoside Triphosphate Hydrolases 229..414 CDD:476819 74/227 (33%)
AAA_lid_3 444..495 CDD:465537 15/50 (30%)
Vps4_C <480..520 CDD:462762 7/34 (21%)
AFG2BNP_076968.2 Required for interaction with AFG2A and CINP. /evidence=ECO:0000269|PubMed:38554706 1..189
CDC48 22..746 CDD:273521 118/416 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 171..203
Blue background indicates that the domain is not in the aligned region.

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