Protein Alignment Fign and Nvl

DIOPT Version :10

• Sequence 1: NP_608763.2
• Gene: Fign / 33544
• FlyBaseID: FBgn0031519
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_080447.1
• Gene: Nvl / 67459
• MGIID: 1914709
• Length: 855
• Species: Mus musculus
• Alignment Length: 490
• Identity: 129/490 - (26%)
• Similarity: 218/490 - (44%)
• Gaps: 96/490 - (19%)

  Fly    45 EKAMKERCQKKITMSRRTKRGITHAGYLFEMPHNSVFEPECRGFYESCQQTEMASSDLQAPALE- 108
            ::|.:||..:  |:.|:.:...|     |...|.:...|   ||         ..:||.|...|
Mouse   435 DEAARERILQ--TLCRKLRLPET-----FNFCHLAHLTP---GF---------VGADLMALCREA 480

  Fly   109 ----VSSTYPVQQA-VKSRPEGQFPESRNNSTKKIDAQQYSSESSSQSGFGFRTAREQLIMDELK 168
                |:.....||| .|.:||.:...|..:..:::.|     |.:|::            .|||:
Mouse   481 AMCAVNRVLMKQQAQQKKKPEIEGLPSEGDQEERLGA-----EPTSET------------QDELQ 528

  Fly   169 K-----KNRQATSEVDAVPTGMMNFRKKTLGGKRTVSSNFVSPVAQNDNSTSSRSSSIPPALAHL 228
            :     :::...||             :.:.|.....::|:..:|:...|.........|
Mouse   529 RLLGLLRDQDPLSE-------------EQMQGLCIELNDFIVALAEVQPSAKREGFVTVP----- 575

  Fly   229 DSKMVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRC-PPRGVLLFGPP 292
                             .|.|.||..||..:...:.||:.|:|.||.|..:.. .|.|:||.|||
Mouse   576 -----------------NVTWADIGALEDIRDELIMAILAPVRNPDQFRTLGLGTPAGILLAGPP 623

  Fly   293 GTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSK 357
            |.||||:||::|:::...|.|:....|.:.:||::|:.|:.:|..|....|.:||.||||:|..:
Mouse   624 GCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPR 688

  Fly   358 RSANENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDEAVRR--RFVRRLYVPLPTRE 420
            ||..|..:::|:.|:.|..:||..:.::  |.::.|||||..:|.|:.|  |..:.|:|.||...
Mouse   689 RSDRETGASVRVVNQLLTEMDGLETRQQ--VFILAATNRPDIIDPAILRPGRLDKTLFVGLPPPA 751

  Fly   421 ARQKIIEKLI-HQVKHNLDVRQVIELAELTDG-----YSGADVDTLCRYASMAPLRSLTPDQMEV 479
            .|..|::.:. :..|..||  :.:.|..:.:.     |:|||:..|.|.||:..||.....|...
Mouse   752 DRVAILKTITKNGTKPPLD--EDVNLETIANDLRCNCYTGADLTALVREASLCALRQEITAQKNG 814

  Fly   480 IETHQLPAVTMDDFKQALRVISKSVSSEDCKQFEA 514
            :...:| .|:...|:.|.:.:..|:|.:|...:||
Mouse   815 VGAGEL-KVSHKHFEDAFKKVKPSISIKDQVMYEA 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_608763.2	PH-like	<4..50	CDD:473070	1/4 (25%)
		P-loop containing Nucleoside Triphosphate Hydrolases	229..414	CDD:476819	64/187 (34%)
		AAA_lid_3	444..495	CDD:465537	15/55 (27%)
		Vps4_C	<480..520	CDD:462762	9/35 (26%)
Nvl	NP_080447.1	Interaction with RPL5. /evidence=ECO:0000250|UniProtKB:O15381	1..219
		Nucleolin_bd	2..72	CDD:465247
		Nucleolar localization signal. /evidence=ECO:0000269|PubMed:21474449	49..52
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..234
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381	85..88
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381	217..231
		CDC48	<242..855	CDD:273521	129/490 (26%)
		Interaction with WDR74. /evidence=ECO:0000250|UniProtKB:O15381	266..473		11/56 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..523		7/31 (23%)