DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fign and FIGNL1

DIOPT Version :9

Sequence 1:	NP_001259995.1	Gene:	Fign / 33544	FlyBaseID:	FBgn0031519	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001036227.1	Gene:	FIGNL1 / 63979	HGNCID:	13286	Length:	674	Species:	Homo sapiens

Alignment Length:	408	Identity:	181/408 - (44%)
Similarity:	255/408 - (62%)	Gaps:	30/408 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 NNSTKKIDAQQYSSESSSQSGFGFRTAREQLIMDELKK---KNRQATSEVDAVPTGMMNFRKKTL 193
            |.:..|.:......:||..:   |:||:|||.:|:.||   ..|.:.|....|        ||:|
Human   275 NKACSKTEDNGPKEDSSLPT---FKTAKEQLWVDQQKKYHQPQRASGSSYGGV--------KKSL 328

  Fly   194 GGKRT--VSSNFVSPVAQNDNSTSSRSSSIPP--------------ALAHLDSKMVDHILGESMH 242
            |..|:  :...||.|:.:.|....:......|              .|.:|:.||::.|:.|.|.
Human   329 GASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIELIMNEIMD 393

  Fly   243 DFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQA 307
            ...||.||||||:|.||:|..|.::.|:.|||:|||:|.||:|:|||||||||||||.|.||||:
Human   394 HGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQS 458

  Fly   308 KAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNE 372
            .|.||||:.|||||||||:.||:|:.|||||...|||:|||||:|||||:|...|:||:.|:|.|
Human   459 GATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTE 523

  Fly   373 FLIHLDGAASNEEIRVLVIGATNRPQELDEAVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHNL 437
            ||:.||||.::.|.|:||:||||||||:|||.|||.|:|||:|||...||::|:..|:.:.:..|
Human   524 FLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMSKEQCCL 588

  Fly   438 DVRQVIELAELTDGYSGADVDTLCRYASMAPLRSLTPDQMEVIETHQLPAVTMDDFKQALRVISK 502
            ...::.::.:.:|.:||||:..|||.||:.|:|||....:..|...|:..:...||:.|.|.:..
Human   589 SEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTVRP 653

  Fly   503 SVSSEDCKQFEAWNEIYG 520
            |||.:|.:.:|.||:.:|
Human   654 SVSPKDLELYENWNKTFG 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fign	NP_001259995.1	AAA	282..418	CDD:214640	93/135 (69%)
		AAA	286..416	CDD:278434	88/129 (68%)
		Vps4_C	<480..520	CDD:286426	13/39 (33%)
FIGNL1	NP_001036227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..179
		Necessary and sufficient for interaction with RAD51. /evidence=ECO:0000305\|PubMed:23754376	295..344		19/56 (34%)
		SpoVK	<374..668	CDD:223540	153/293 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157786
Domainoid	1	1.000	186	1.000	Domainoid score	I3365
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11063
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2414
Isobase	1	0.950	-	0	Normalized mean entropy	S1759
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1176820at2759
OrthoFinder	1	1.000	-	-		FOG0001088
OrthoInspector	1	1.000	-	-		otm41146
orthoMCL	1	0.900	-	-		OOG6_100722
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2527
SonicParanoid	1	1.000	-	-		X1766
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.840